{"id":"W4308203682","doi":"10.3390/epigenomes6040040","title":"Regulation of Polyhomeotic Condensates by Intrinsically Disordered Sequences That Affect Chromatin Binding","year":2022,"lang":"en","type":"article","venue":"Epigenomes","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Chromatin; Biophysics; Protein subunit; Chemistry; Nucleosome; DNA; Nucleus; Biochemistry; Cell biology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001976034,0.0001307908,0.0001761563,0.00005485444,0.0001755893,0.00001898433,0.0002281487,0.00005148734,0.0001579317],"category_scores_gemma":[0.00002693866,0.0001341244,0.00008162345,0.0001085445,0.00007778646,0.000003460851,0.0001936809,0.0000686006,0.000003770205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003616276,"about_ca_system_score_gemma":0.00006145181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003259582,"about_ca_topic_score_gemma":0.00001351791,"domain_scores_codex":[0.999091,0.00008853235,0.0002122409,0.0002489737,0.0001646932,0.0001945679],"domain_scores_gemma":[0.9994794,0.0000254002,0.0001896476,0.0002401096,0.00002419632,0.00004124616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001916091,0.00004692806,0.007110913,0.0000256029,0.00005288104,7.488156e-7,0.0001639422,0.000566216,0.990582,0.0001284014,0.0005095768,0.0007935989],"study_design_scores_gemma":[0.001443008,0.001429679,0.04634836,0.00002236457,0.00006809689,0.00003714197,0.002545788,0.00200911,0.9311966,0.001643985,0.01243564,0.0008202578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975786,0.001356132,0.0001587459,0.0001452414,0.0001468845,0.0001898594,0.0001385134,0.00001264162,0.0002734463],"genre_scores_gemma":[0.9980371,0.00009710585,0.0004307925,0.00003653629,0.00004080365,0.00002646718,0.0005530016,0.00002196713,0.0007562366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05938547,"threshold_uncertainty_score":0.5469436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007646325046679288,"score_gpt":0.2183466554230106,"score_spread":0.2107003303763313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}