{"id":"W4308210073","doi":"10.1038/s41467-022-34129-4","title":"Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer’s disease","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Joseph's Health Care; University of British Columbia Hospital; Sunnybrook Health Science Centre; St Joseph's Health Centre; McGill University; Jewish General Hospital","funders":"National Institute on Aging; Fonds de Recherche du Québec - Santé; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Parkinsonfonden; National Institutes of Health; IXICO; H. Lundbeck A/S; Genentech; Marcus och Amalia Wallenbergs minnesfond; Skånes universitetssjukhus; Vetenskapsrådet; Eisai; Lunds Universitet; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Svenska Forskningsrådet Formas; Northern California Institute for Research and Education; Servier; Knut och Alice Wallenbergs Stiftelse; Pfizer; Biogen; BioClinica; Hjärnfonden; Australian Government; F. Hoffmann-La Roche; University of Southern California; Bristol-Myers Squibb; U.S. Department of Defense; Eli Lilly and Company; BrightFocus Foundation; Novartis Pharmaceuticals Corporation; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Tau pathology; Dementia; Cognitive decline; Tau protein; Cognition; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Amyloid (mycology); Neuroscience; Disease; Alzheimer's disease; Chemistry; Cognitive impairment; Internal medicine; Psychology; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000968558,0.0005170854,0.0003810054,0.0008773588,0.0001752437,0.0006089923,0.0002032438,0.0005428166,0.000993466],"category_scores_gemma":[0.002286047,0.000251192,0.000205513,0.0007393101,0.0002639581,0.0006287951,0.0002747408,0.0006961119,0.0002537283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000171095,"about_ca_system_score_gemma":0.0002028838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001021783,"about_ca_topic_score_gemma":0.0009457754,"domain_scores_codex":[0.9997926,0.0000539961,0.00002154531,0.00005255534,0.00005648779,0.00002271112],"domain_scores_gemma":[0.9986469,0.0002760283,0.0007181444,0.00008349347,0.0001606062,0.000114846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005622988,0.0007587947,0.8622344,0.0003672801,0.000478695,0.0009224887,0.000876409,0.0009172244,0.06253094,0.0004949095,0.0009073931,0.06388856],"study_design_scores_gemma":[0.0000155451,0.0004665057,0.9934211,0.00002102806,0.00007463084,0.000628633,0.0001093641,0.0005159283,0.003464205,0.0007424477,0.0005308828,0.000009760184],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912867,0.005991265,0.0009413445,0.0001480562,0.00003254188,0.00001356062,0.0002415533,0.00002316886,0.00132183],"genre_scores_gemma":[0.995732,0.002233709,0.0009567657,0.00007945657,0.00007383705,0.00001740541,0.0002606804,0.000008835296,0.0006373753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001021783,"threshold_uncertainty_score":0.005122304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03509244652088044,"score_gpt":0.3573503108682206,"score_spread":0.3222578643473401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}