{"id":"W4308210367","doi":"10.1038/s42003-022-04160-8","title":"Antigenic mapping reveals sites of vulnerability on α-HCoV spike protein","year":2022,"lang":"en","type":"article","venue":"Communications Biology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"ShanghaiTech University; Ministry of Science and Technology of the People's Republic of China; Shanghai Municipal Education Commission; National Natural Science Foundation of China","keywords":"Epitope; Epitope mapping; Antigen; Virology; Biology; Antibody; Computational biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001037137,0.00008909829,0.0002702539,0.0002150063,0.0003282911,0.000004023598,0.0007864427,0.00007181271,0.0000828878],"category_scores_gemma":[0.0005515429,0.000081904,0.00009586105,0.0004139887,0.0003784134,0.0000178424,0.0008429267,0.0005729047,0.0000363711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001168559,"about_ca_system_score_gemma":0.0001880177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001216043,"about_ca_topic_score_gemma":0.00002056539,"domain_scores_codex":[0.9983773,0.0007406868,0.0003296812,0.0002148204,0.000134576,0.0002029204],"domain_scores_gemma":[0.9970281,0.0004061282,0.0001096703,0.002310805,0.0001252807,0.00002005415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009660309,0.0004870701,0.1504677,0.00004806464,0.00004563459,0.000001299977,0.0002716255,4.555161e-7,0.8363947,0.006703448,0.0001791511,0.005304279],"study_design_scores_gemma":[0.001718836,0.001997934,0.06183212,0.00008715884,0.00003155292,0.00004071319,0.001068688,0.0006245078,0.1438482,0.01215104,0.7763038,0.0002955207],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862265,0.001666569,0.00005662349,0.003061757,0.00002588888,0.0007302971,0.00003691087,0.00004751287,0.008147933],"genre_scores_gemma":[0.9922042,0.00001914481,0.001193786,0.006068464,0.00002015881,0.0003657708,0.00005552454,0.000009172998,0.00006375746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7761246,"threshold_uncertainty_score":0.3339948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1464342756818483,"score_gpt":0.417773572462624,"score_spread":0.2713392967807757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}