{"id":"W4308210367","doi":"10.1038/s42003-022-04160-8","title":"Antigenic mapping reveals sites of vulnerability on α-HCoV spike protein","year":2022,"lang":"en","type":"article","venue":"Communications Biology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"ShanghaiTech University; Ministry of Science and Technology of the People's Republic of China; Shanghai Municipal Education Commission; National Natural Science Foundation of China","keywords":"Epitope; Epitope mapping; Antigen; Virology; Biology; Antibody; Computational biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005144889,0.0001356956,0.00009196512,0.0002111758,0.0001139848,0.0001789358,0.00008335563,0.0001773576,0.0008902446],"category_scores_gemma":[0.00008853386,0.00006956554,0.0001386569,0.0001319662,0.0001086005,0.0001336304,0.0001274445,0.0002046606,0.0002243466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001404699,"about_ca_system_score_gemma":0.0001005491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001337526,"about_ca_topic_score_gemma":0.001394038,"domain_scores_codex":[0.9999605,0.000004150056,0.00000263193,0.000009074657,0.000008122447,0.00001552894],"domain_scores_gemma":[0.9999554,0.000008285664,0.00001006869,0.000005084123,0.000008210355,0.0000129747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006577741,0.000007852247,0.002741415,0.000008982852,0.000003464176,0.00007598544,0.00002556847,0.0000572998,0.9960163,0.00006705992,0.00002402909,0.0009063128],"study_design_scores_gemma":[0.00002183244,0.0005388762,0.3331081,0.00001817792,0.00003686345,0.002896893,0.0004390705,0.004788371,0.6538091,0.0004760167,0.003855682,0.00001114213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99782,0.0001784194,0.0007981569,0.00002386983,0.000002765205,0.000005260174,0.00007510628,0.000008640308,0.001087938],"genre_scores_gemma":[0.9983931,0.0001352069,0.0006799017,0.00004098397,0.000002806674,0.000003365202,0.0002275892,0.000003763073,0.0005132334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001337526,"threshold_uncertainty_score":0.002978206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1464342756818483,"score_gpt":0.417773572462624,"score_spread":0.2713392967807757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}