{"id":"W4308213083","doi":"10.1016/j.ceca.2022.102671","title":"Structural and functional conservation of the activating Ca2+ binding site in inositol 1,4.5-trisphosphate and ryanodine receptors","year":2022,"lang":"en","type":"letter","venue":"Cell Calcium","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Ryanodine receptor; Endoplasmic reticulum; Inositol; Receptor; Chemistry; Inositol trisphosphate receptor; Inositol trisphosphate; Biochemistry; Binding site; Inositol phosphate; Biophysics; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007034597,0.0002877053,0.0005417624,0.0001495317,0.0006840735,0.00065891,0.0006777646,0.00538529,0.002019944],"category_scores_gemma":[0.002076191,0.0002055993,0.0004226995,0.0001287123,0.0008198996,0.000442416,0.0002588866,0.004324312,0.001199862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001120037,"about_ca_system_score_gemma":0.0005193207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001120995,"about_ca_topic_score_gemma":0.001387555,"domain_scores_codex":[0.9997126,0.00007073383,0.00003596823,0.00003884975,0.00008342545,0.00005827635],"domain_scores_gemma":[0.9993042,0.0003642435,0.00006885757,0.00005072569,0.00009783434,0.0001142297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007934188,0.000510353,0.004640307,0.0004264596,0.000151258,0.05338334,0.0004487733,0.001589461,0.1035351,0.02225021,0.7212327,0.08389782],"study_design_scores_gemma":[0.002050096,0.001275523,0.02272132,0.0002080164,0.0002727669,0.04307793,0.0007287163,0.008340368,0.07070124,0.03091182,0.8194941,0.0002182039],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1258516,0.01197228,0.003090832,0.7095674,0.1256174,0.00008640189,0.0004931403,0.0002492466,0.02307182],"genre_scores_gemma":[0.5571898,0.006870119,0.002347827,0.329917,0.06766496,0.000114025,0.0004049643,0.0001124065,0.03537894],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00538529,"threshold_uncertainty_score":0.008126438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01618198686612621,"score_gpt":0.2217846770639671,"score_spread":0.2056026901978409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}