{"id":"W4308216135","doi":"10.1093/narcan/zcac034","title":"Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation","year":2022,"lang":"en","type":"article","venue":"NAR Cancer","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Canadian Institutes of Health Research; Cancer Research Society; Canadian Urological Association Scholarship Fund; Urology Care Foundation","keywords":"Enzalutamide; Polysome; Prostate cancer; Cancer research; Translation (biology); Downregulation and upregulation; Messenger RNA; Biology; Cancer; Computational biology; Gene; Genetics; RNA; Ribosome; Androgen receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009958719,0.0004167384,0.0002151551,0.0002951608,0.0000992744,0.0004058341,0.0001592524,0.0001814141,0.0009614803],"category_scores_gemma":[0.00006428986,0.0001591557,0.000265867,0.0002061442,0.0002261558,0.0001454574,0.0002009277,0.00041245,0.0002448703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002454841,"about_ca_system_score_gemma":0.0001609477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005987004,"about_ca_topic_score_gemma":0.00103788,"domain_scores_codex":[0.9998696,0.00001930292,0.00001199765,0.00003469477,0.00004211416,0.00002226958],"domain_scores_gemma":[0.9998907,0.00001170748,0.00004886032,0.00001643714,0.00001204947,0.00002028903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000458544,0.000008957231,0.0003058571,0.00002000027,0.000006624936,0.00003300149,0.000003853233,0.00006061347,0.998771,0.0000414038,0.00002068666,0.000682085],"study_design_scores_gemma":[0.00001064471,0.0003745386,0.01832422,0.000006540391,0.00002946447,0.000420799,0.00002984179,0.001848688,0.975486,0.0000778381,0.00338197,0.000009467034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903234,0.002506115,0.005095997,0.00009977497,0.00002814255,0.00002439012,0.0005382393,0.0002076061,0.001176266],"genre_scores_gemma":[0.9950058,0.0008329793,0.001600726,0.00004381945,0.000007913173,0.00001977085,0.0005409978,0.00002694113,0.001921111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009614803,"threshold_uncertainty_score":0.003216505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02047243242797043,"score_gpt":0.3097729331238543,"score_spread":0.2893005006958839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}