{"id":"W4308216135","doi":"10.1093/narcan/zcac034","title":"Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation","year":2022,"lang":"en","type":"article","venue":"NAR Cancer","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Canadian Institutes of Health Research; Cancer Research Society; Canadian Urological Association Scholarship Fund; Urology Care Foundation","keywords":"Enzalutamide; Polysome; Prostate cancer; Cancer research; Translation (biology); Downregulation and upregulation; Messenger RNA; Biology; Cancer; Computational biology; Gene; Genetics; RNA; Ribosome; Androgen receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001449873,0.0001203618,0.0001210422,0.00005764261,0.0001291793,0.00001146491,0.00009194903,0.00007295593,0.0002256162],"category_scores_gemma":[0.000009719916,0.0001318935,0.00006744856,0.0002976925,0.00003965907,0.000007795357,0.0000395186,0.00008944305,3.948847e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001557541,"about_ca_system_score_gemma":0.000251926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002754991,"about_ca_topic_score_gemma":0.001859176,"domain_scores_codex":[0.9988225,0.00008349901,0.0001991925,0.0003342779,0.0003726942,0.0001878435],"domain_scores_gemma":[0.9995966,0.00000689655,0.00007918687,0.0001410198,0.0001063229,0.00006996094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00103345,0.0000434589,0.006992204,0.00007834568,0.00008436466,0.000001010122,0.0003998294,0.01603949,0.9464884,0.0001768664,0.0008286858,0.02783385],"study_design_scores_gemma":[0.003990781,0.0007812409,0.02779546,0.0001130346,0.0001332118,0.000008741942,0.000305516,0.001631039,0.817184,0.0008798063,0.146424,0.0007531765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790509,0.00971684,0.008138874,0.00110431,0.0002244743,0.0006797978,0.0007708623,0.00001315671,0.0003007416],"genre_scores_gemma":[0.9981671,0.0002935779,0.000518897,0.00009266434,0.0000592614,0.0002610361,0.000198212,0.00001907783,0.0003901872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1455953,"threshold_uncertainty_score":0.5378458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02047243242797043,"score_gpt":0.3097729331238543,"score_spread":0.2893005006958839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}