{"id":"W4308274680","doi":"10.1101/2022.11.04.515196","title":"Nucleolar Reorganization After Cellular Stress is Orchestrated by SMN Shuttling between Nuclear Compartments","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Institut National Du Cancer; Jazan University; University of Ottawa","keywords":"Nucleolus; Fibrillarin; Cell biology; Biology; Ribosome biogenesis; Cajal body; DNA repair; Genetics; DNA; Ribosome; Nucleus; RNA; Gene; RNA splicing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003044516,0.0005931029,0.0004643514,0.0001459033,0.0002537438,0.0001914604,0.0005658437,0.0008377847,0.0003946822],"category_scores_gemma":[0.00004789183,0.0007662828,0.0001662548,0.0004332903,0.00009843872,0.00001736889,0.0008053596,0.0006689723,0.00004541812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003359215,"about_ca_system_score_gemma":0.0003389167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004265313,"about_ca_topic_score_gemma":0.000001445228,"domain_scores_codex":[0.9968787,0.0002174943,0.0006049712,0.001312067,0.0004679281,0.0005188624],"domain_scores_gemma":[0.997613,0.00001061706,0.0004877222,0.001306063,0.0003430063,0.0002396079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007029603,0.0001110288,0.0222224,0.0001589528,0.0003704078,0.00000968498,0.000017861,0.0005334587,0.9739869,0.000008896181,0.002507837,0.000002297316],"study_design_scores_gemma":[0.0006489229,0.0001159324,0.03193956,0.0001333328,0.0002485521,1.312159e-8,0.000006875837,0.0003899981,0.9230527,9.914253e-7,0.04251019,0.0009529053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935252,0.002071291,0.001060231,0.0001386449,0.0006427817,0.0007194328,0.001662563,0.0001716379,0.000008209245],"genre_scores_gemma":[0.9975402,0.0002841041,0.0008139457,0.0001690508,0.0006761369,0.00009911506,0.00009930914,0.0002932888,0.00002484017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05093416,"threshold_uncertainty_score":0.9994788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007893136808031043,"score_gpt":0.2078607675950224,"score_spread":0.1999676307869913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}