{"id":"W4308275254","doi":"10.1101/2022.11.05.515295","title":"Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; PHENOMIN; University of Ottawa","keywords":"Mitochondrial DNA; Biology; MT-RNR1; Mitochondrion; Gene expression; Gene; Cell biology; Population; Translation (biology); Genetics; Messenger RNA; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004661399,0.0008086275,0.0005124002,0.001149215,0.0003337474,0.0006142175,0.0006204867,0.0009909038,0.005025626],"category_scores_gemma":[0.0002288562,0.0004350299,0.0005251414,0.0003349594,0.0008889193,0.0004103626,0.0004256671,0.001503417,0.001561148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004665484,"about_ca_system_score_gemma":0.0002990653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006235437,"about_ca_topic_score_gemma":0.001006704,"domain_scores_codex":[0.9996108,0.00005573751,0.00005441604,0.000115164,0.00009491366,0.00006880302],"domain_scores_gemma":[0.999334,0.00008616143,0.0002711157,0.0001001819,0.00004549795,0.0001629287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004262339,0.00006989461,0.000241406,0.00003924219,0.00001564194,0.00006287855,0.00002328486,0.00007069328,0.9973575,0.0002468921,0.0001235478,0.001322753],"study_design_scores_gemma":[0.0001259057,0.0006445029,0.004226437,0.00002806921,0.00004927015,0.0003627333,0.00005935502,0.000810705,0.9883024,0.0001938446,0.005180269,0.00001651707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784759,0.001279482,0.009988494,0.0006365205,0.0001631329,0.00009744091,0.005851364,0.0007605823,0.002747098],"genre_scores_gemma":[0.9493002,0.001648776,0.01368937,0.0005766641,0.00008460999,0.0004619652,0.00632931,0.001262311,0.02664681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005025626,"threshold_uncertainty_score":0.01681238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01628129642647579,"score_gpt":0.253718573576162,"score_spread":0.2374372771496862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}