{"id":"W4308294091","doi":"10.1002/alz.12817","title":"Fragmentation of rest periods, astrocyte activation, and cognitive decline in older adults with and without Alzheimer's disease","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Centre for Addiction and Mental Health; Sunnybrook Health Science Centre","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Krembil Foundation; University of Toronto","keywords":"Astrocyte; Cognition; Prefrontal cortex; Neuroscience; Cognitive decline; Fragmentation (computing); Psychology; Actigraphy; Alzheimer's disease; Gerontology; Biology; Medicine; Disease; Circadian rhythm; Internal medicine; Dementia; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003169012,0.0001749664,0.0002243582,0.0004122189,0.0002421393,0.0003096882,0.0001422759,0.0001774307,0.000593071],"category_scores_gemma":[0.0007343629,0.00008871759,0.000229769,0.000376911,0.0001576733,0.0001676331,0.0002574012,0.0002028502,0.00008025811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002216923,"about_ca_system_score_gemma":0.0001611891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005832106,"about_ca_topic_score_gemma":0.01392612,"domain_scores_codex":[0.9999138,0.00001678792,0.00001053104,0.00002855641,0.00001663093,0.00001360406],"domain_scores_gemma":[0.9996357,0.0000361084,0.0002039112,0.0000220912,0.00005609282,0.00004604254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007776342,0.00005755141,0.984208,0.00008420816,0.0002049474,0.00006957939,0.0003622114,0.0001103033,0.004664622,0.00002517767,0.0002303348,0.009205469],"study_design_scores_gemma":[0.000003234093,0.00005752627,0.9994849,0.000007591922,0.00002424864,0.00004231895,0.00007870238,0.00005631756,0.0001329973,0.00003494869,0.00007543369,0.000001729229],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985957,0.0006497926,0.0001148643,0.00003069869,0.000003244202,0.00000441129,0.0004143334,0.000003132901,0.0001838628],"genre_scores_gemma":[0.9988476,0.0002833007,0.0001977335,0.00004463494,0.000006498393,0.00001054842,0.0004207734,0.000001608726,0.0001873359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005832106,"threshold_uncertainty_score":0.01159632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02615394545984699,"score_gpt":0.2971002977234097,"score_spread":0.2709463522635627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}