{"id":"W4308303580","doi":"10.1186/s44149-022-00053-9","title":"Altered gene expression in human brain microvascular endothelial cells in response to the infection of influenza H1N1 virus","year":2022,"lang":"en","type":"article","venue":"Animal Diseases","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"Fundamental Research Funds for the Central Universities; Huazhong Agricultural University","keywords":"Biology; Proinflammatory cytokine; Innate immune system; Immunology; Neuroinflammation; Immune system; Virus; Chemokine; Transcriptome; Microglia; Interferon; Pattern recognition receptor; Human brain; Influenza A virus; Virology; Gene expression; Inflammation; Gene; Neuroscience; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008339498,0.0001199693,0.00018423,0.0002454991,0.0001574945,0.0002603864,0.00006134524,0.0001727308,0.000767269],"category_scores_gemma":[0.0001303218,0.0000828415,0.0001746972,0.0003156984,0.0001218408,0.0001031241,0.00009270111,0.0002618029,0.0002042635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001341991,"about_ca_system_score_gemma":0.0001093152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001090734,"about_ca_topic_score_gemma":0.0009799924,"domain_scores_codex":[0.9998797,0.00001294293,0.000008210361,0.00003674151,0.00002453911,0.00003782208],"domain_scores_gemma":[0.9999455,0.00001137631,0.00001147938,0.000005004978,0.00001687807,0.000009711422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002014511,0.00002443702,0.002259856,0.00004209766,0.00001226408,0.0001298261,0.00009396256,0.00003400879,0.9956924,0.00003702514,0.00004913855,0.001423541],"study_design_scores_gemma":[0.00003182025,0.001156914,0.3241904,0.00002582166,0.0001231596,0.001424409,0.0007360381,0.002007705,0.6650474,0.0001958403,0.005029049,0.00003150642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995618,0.001519362,0.0008612656,0.00004470766,0.00002592735,0.00001633468,0.001196082,0.00001747696,0.0007009179],"genre_scores_gemma":[0.993034,0.001214971,0.001449424,0.0001038601,0.00002233758,0.00007556375,0.002150134,0.000006785112,0.001942918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001090734,"threshold_uncertainty_score":0.002566755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01329619456863438,"score_gpt":0.2687982144739618,"score_spread":0.2555020199053274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}