{"id":"W4308310991","doi":"10.1016/j.jddst.2022.103950","title":"The effects of cell culture conditions on premature hydrolysis of traceless ester-linked disulfide linkers","year":2022,"lang":"en","type":"article","venue":"Journal of Drug Delivery Science and Technology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; Victoria University","keywords":"Prodrug; Chemistry; Hydrolysis; Biochemistry; In vitro; Combinatorial chemistry; Cell culture; Drug delivery; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000857057,0.0005798349,0.0004483395,0.000187899,0.0002282976,0.0005029541,0.0003900479,0.0004528662,0.001556315],"category_scores_gemma":[0.0009669501,0.0002425025,0.0003696005,0.0002831522,0.000331527,0.0004586409,0.0003099352,0.0007229394,0.0003678588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004417426,"about_ca_system_score_gemma":0.0005255989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002308791,"about_ca_topic_score_gemma":0.004043706,"domain_scores_codex":[0.9993238,0.0002207659,0.0001109259,0.0001131539,0.0001166268,0.0001146773],"domain_scores_gemma":[0.9988601,0.0006283138,0.0001507954,0.0001258719,0.0001700348,0.00006491126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005857277,0.00007330791,0.0002718283,0.00005231516,0.00001641331,0.00007252263,0.00007901765,0.0001039733,0.9967824,0.00007885219,0.00009220751,0.001791424],"study_design_scores_gemma":[0.000006968646,0.0001605629,0.0007388653,0.000003770504,0.00001248413,0.00003500563,0.00002052641,0.0002047401,0.9981921,0.00001040426,0.0006105931,0.000003850779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901437,0.003085818,0.00346591,0.0001851155,0.000107395,0.00006866298,0.0007863395,0.00006399532,0.002093007],"genre_scores_gemma":[0.9905071,0.001545193,0.004185661,0.0001167105,0.00002611551,0.00007273873,0.001282923,0.00007954105,0.002184044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002308791,"threshold_uncertainty_score":0.005206347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002742793721988162,"score_gpt":0.2139328996610387,"score_spread":0.2111901059390505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}