{"id":"W4308319341","doi":"10.1016/j.clml.2022.11.002","title":"Azacitidine Monotherapy in Patients With Treatment-Naïve Higher-risk Myelodysplastic Syndrome: A Systematic Literature Review and Meta-analysis","year":2022,"lang":"en","type":"review","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Internal medicine; Azacitidine; Observational study; Meta-analysis; Myelodysplastic syndromes; Adverse effect; Randomized controlled trial; Incidence (geometry); Retrospective cohort study","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","metaepi_broad","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.002803671,0.002338841,0.02768019,0.001823213,0.0002827571,0.0002036019,0.0009722318,0.001299558,0.001975173],"category_scores_gemma":[0.001374448,0.001369832,0.006733675,0.006794027,0.0004974413,0.0002597327,0.0004316861,0.002134582,0.0001656477],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007413663,"about_ca_system_score_gemma":0.003275478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009018939,"about_ca_topic_score_gemma":0.00002613268,"domain_scores_codex":[0.9838545,0.004796707,0.005377125,0.0029669,0.001696089,0.001308635],"domain_scores_gemma":[0.9863166,0.006126973,0.002804611,0.003328069,0.0003560348,0.001067713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0005295067,0.000924549,0.0008395748,0.4085045,0.3235137,0.004178746,0.00005245257,0.000002277751,4.87742e-9,0.00002954711,0.0006194098,0.2608058],"study_design_scores_gemma":[0.006452827,0.003154388,0.01337475,0.04442816,0.7706141,0.0007755281,0.000006520093,0.00002873869,2.182038e-8,0.00001007547,0.1600009,0.001153933],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007454776,0.9862768,0.00001076661,0.0001465041,0.0001172363,0.01112038,0.00122077,0.000162124,0.0001999126],"genre_scores_gemma":[0.0002271273,0.9860214,0.0004316622,0.0008987766,0.0001170553,0.005000182,0.002780676,0.0003866873,0.004136442],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4471004,"threshold_uncertainty_score":0.999997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06970053631404995,"score_gpt":0.366825684225709,"score_spread":0.2971251479116591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}