{"id":"W4308322220","doi":"10.1007/s10875-022-01385-4","title":"Disseminated Acanthamoeba Infection in a Bone Marrow Transplant Recipient with CTLA-4 Haploinsufficiency","year":2022,"lang":"en","type":"letter","venue":"Journal of Clinical Immunology","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medical microbiology; Haploinsufficiency; Medicine; Immunology; Bone marrow transplantation; Bone marrow transplant; Acanthamoeba; Bone marrow; Biology; Microbiology; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.001761,0.0003415383,0.00103491,0.0004227259,0.00009792518,0.00002819232,0.000586583,0.00133895,0.0002578127],"category_scores_gemma":[0.0005439403,0.0002585834,0.0004785997,0.0003470182,0.000449302,0.00001126223,0.0001741839,0.005344118,0.000007082897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008535354,"about_ca_system_score_gemma":0.0008061072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00012476,"about_ca_topic_score_gemma":0.00008171862,"domain_scores_codex":[0.9955146,0.001024616,0.001807562,0.0005209866,0.0005331,0.0005990996],"domain_scores_gemma":[0.9976892,0.0002894641,0.00117854,0.0004613883,0.000287465,0.0000938761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01630314,0.00320119,0.09311613,0.0002575645,0.002477061,0.01939493,0.0002797678,0.0002234584,0.07741947,0.00001570057,0.7726533,0.01465828],"study_design_scores_gemma":[0.004003058,0.01240015,0.02191693,0.000296443,0.0001731071,0.003317392,0.00004145145,0.00001845357,0.002921634,0.0000400532,0.9543372,0.0005341233],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9097621,0.002633541,0.0001233346,0.08509191,0.00155873,0.0002810037,0.00003584508,0.000008051328,0.0005054541],"genre_scores_gemma":[0.9131103,0.02769414,0.0001793846,0.05096909,0.004380247,0.00005444084,0.0005858869,0.000145624,0.002880933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1816839,"threshold_uncertainty_score":0.9999866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02825658929199264,"score_gpt":0.3350801613841617,"score_spread":0.306823572092169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}