{"id":"W4308326586","doi":"10.1016/j.isci.2022.105487","title":"Cell-free DNA methylation-defined prognostic subgroups in small-cell lung cancer identified by leukocyte methylation subtraction","year":2022,"lang":"en","type":"article","venue":"iScience","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Princess Margaret Cancer Centre; Canada Research Chairs; St Mary's Hospital Centre; University of Toronto","funders":"Memorial Sloan-Kettering Cancer Center; University of Toronto; Canada Foundation for Innovation; National Cancer Institute; National Institutes of Health; Ontario Institute for Cancer Research; Canadian Institutes of Health Research; Cancer Research Society","keywords":"DNA methylation; Methylation; Biology; Methylated DNA immunoprecipitation; Differentially methylated regions; Epigenomics; Cancer research; Epigenetics; Lung cancer; Molecular biology; DNA; Genetics; Oncology; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001897623,0.0001445949,0.0002337281,0.0004551529,0.0001885001,0.0002760339,0.0001436744,0.0001894246,0.0009274623],"category_scores_gemma":[0.0004523872,0.00008221131,0.0001502016,0.0003213547,0.0001252435,0.0001166951,0.0002750477,0.0002156712,0.0001629844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001664909,"about_ca_system_score_gemma":0.0002150612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001346717,"about_ca_topic_score_gemma":0.003783751,"domain_scores_codex":[0.9998921,0.00001933322,0.000007835808,0.00003712731,0.00002561739,0.00001792567],"domain_scores_gemma":[0.9998808,0.00003747043,0.00002932595,0.00001536243,0.00002065687,0.00001644005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008208178,0.00003930784,0.2781274,0.0001229025,0.0002074686,0.0001545943,0.0002269244,0.0007726795,0.6837736,0.000216697,0.000525292,0.03501235],"study_design_scores_gemma":[0.00004200906,0.000442484,0.8316298,0.00002672615,0.0002291078,0.001140362,0.0003306218,0.006562236,0.1538466,0.0007830276,0.004948143,0.00001882575],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957703,0.000610762,0.002245842,0.00005637149,0.000004071412,0.00001671294,0.0009271,0.00003636064,0.0003325476],"genre_scores_gemma":[0.9968432,0.0001613149,0.001361294,0.00003960375,0.000004033873,0.00001741732,0.001249832,0.000007053588,0.0003161797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001346717,"threshold_uncertainty_score":0.003102601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02733312170254544,"score_gpt":0.3252409477923015,"score_spread":0.2979078260897561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}