{"id":"W4308335701","doi":"10.31083/j.fbl2711301","title":"Antibody-Drug Conjugates Targeting Tumor-Specific Mucin Glycoepitopes","year":2022,"lang":"en","type":"review","venue":"Frontiers in Bioscience-Landmark","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Monoclonal antibody; Epitope; Antibody-drug conjugate; Glycosylation; MUC1; Cancer research; Antibody; Glycomics; Drug; Glycan; Mucin; Chemistry; Medicine; Pharmacology; Glycoprotein; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001548581,0.0005840998,0.001149593,0.0006222454,0.0004292978,0.0001848567,0.001430153,0.0002698495,0.0004133062],"category_scores_gemma":[0.0003926014,0.0005051325,0.0004256977,0.001240974,0.0004059016,0.00001798644,0.0006853443,0.0007296895,0.00004095727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001723142,"about_ca_system_score_gemma":0.0005558844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005651815,"about_ca_topic_score_gemma":0.00001405357,"domain_scores_codex":[0.9955255,0.0006021693,0.0008441843,0.001392617,0.0006969918,0.0009385177],"domain_scores_gemma":[0.9985166,0.00005988095,0.0003675605,0.0007632007,0.00006448459,0.0002283154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001482219,0.0003105892,0.002626479,0.003613125,0.0001311588,0.0002386501,0.0001707185,0.00002173394,0.002777388,0.00007167953,0.1920138,0.7978764],"study_design_scores_gemma":[0.0003716659,0.0001168755,0.00002099261,0.0005699342,0.00002190788,0.00003394997,0.0002098264,0.00005270309,0.0002526915,0.00003294776,0.997696,0.000620509],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003925146,0.9928966,0.0006722726,0.00004297672,0.00222929,0.001128915,0.0001532032,0.00003216628,0.002452079],"genre_scores_gemma":[0.0002004168,0.9925654,0.002719754,0.00008990911,0.0004006075,0.0002146298,0.001759311,0.00007181431,0.001978193],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8056822,"threshold_uncertainty_score":0.99974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02701278204641938,"score_gpt":0.3218361265229002,"score_spread":0.2948233444764808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}