{"id":"W4308335701","doi":"10.31083/j.fbl2711301","title":"Antibody-Drug Conjugates Targeting Tumor-Specific Mucin Glycoepitopes","year":2022,"lang":"en","type":"review","venue":"Frontiers in Bioscience-Landmark","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Monoclonal antibody; Epitope; Antibody-drug conjugate; Glycosylation; MUC1; Cancer research; Antibody; Glycomics; Drug; Glycan; Mucin; Chemistry; Medicine; Pharmacology; Glycoprotein; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002682454,0.0005971276,0.0006570541,0.001105651,0.0001195394,0.0004833219,0.0004068216,0.0006075653,0.001972449],"category_scores_gemma":[0.0002799154,0.0001657443,0.0002413904,0.001145988,0.0002013944,0.0006691779,0.0003328691,0.001026658,0.001587705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003985328,"about_ca_system_score_gemma":0.000520363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004121417,"about_ca_topic_score_gemma":0.0007544779,"domain_scores_codex":[0.9999131,0.00001245748,0.000007971563,0.00001437777,0.00004071513,0.00001133213],"domain_scores_gemma":[0.9999369,0.00002399958,0.00001003798,0.000002667859,0.00001819706,0.000008140099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008046265,0.00008231642,0.0001219232,0.01242528,0.00006416124,0.0002172719,0.0000361871,0.0005574867,0.01293586,0.005098133,0.02061088,0.94777],"study_design_scores_gemma":[0.00001662052,0.00009614049,0.0004151565,0.0009631683,0.00005114121,0.0009038298,0.00001707968,0.0001144067,0.002975249,0.0008789994,0.9935585,0.000009826626],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005325486,0.996142,0.000477396,0.0002090024,0.0002833463,0.00001225099,0.00003079271,0.00001573554,0.002296962],"genre_scores_gemma":[0.001963215,0.9955357,0.0004541746,0.0001894287,0.0000861119,0.00001420676,0.0000604926,0.000002424915,0.001694129],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001972449,"threshold_uncertainty_score":0.006598473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02701278204641938,"score_gpt":0.3218361265229002,"score_spread":0.2948233444764808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}