{"id":"W4308340884","doi":"10.1126/sciadv.abo7247","title":"The HUSH complex controls brain architecture and protocadherin fidelity","year":2022,"lang":"en","type":"article","venue":"Science Advances","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Protocadherin; Gene silencing; Phosphoprotein; Biology; Neuroscience; Epigenetics; Cell biology; Gene; Genetics; Phosphorylation; Cadherin; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007560352,0.0002064963,0.000131808,0.0002071909,0.000159651,0.0003664863,0.000203241,0.0001748467,0.0009332031],"category_scores_gemma":[0.0001463147,0.000114479,0.00008497619,0.00007747595,0.0003367007,0.0002006182,0.000438984,0.0002425277,0.0002372549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004400721,"about_ca_system_score_gemma":0.0002502574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007478794,"about_ca_topic_score_gemma":0.001922489,"domain_scores_codex":[0.9999028,0.00001046766,0.000004508322,0.00002851413,0.00003042066,0.00002326412],"domain_scores_gemma":[0.9999015,0.00001238427,0.00003469121,0.00001112249,0.00001053024,0.00002973285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000511045,0.000002590931,0.0005782234,0.000007648561,0.000004074295,0.00003845023,0.00001443387,0.00008638606,0.9971331,0.000401168,0.0000315961,0.001651199],"study_design_scores_gemma":[0.000007700385,0.00004470188,0.0199253,0.000002638755,0.000008323608,0.0001644111,0.0000431058,0.002110736,0.9755152,0.0004169617,0.001753258,0.0000075324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993912,0.0005204905,0.003646221,0.00005451051,0.00001198493,0.000004674278,0.0001439377,0.0001238589,0.001582317],"genre_scores_gemma":[0.9973117,0.0001840843,0.0008624878,0.00001103729,0.000002611044,0.0000036965,0.00007926254,0.00001718558,0.001527943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009332031,"threshold_uncertainty_score":0.003192961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183371277904127,"score_gpt":0.301451770972911,"score_spread":0.2896180581938698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}