{"id":"W4308340884","doi":"10.1126/sciadv.abo7247","title":"The HUSH complex controls brain architecture and protocadherin fidelity","year":2022,"lang":"en","type":"article","venue":"Science Advances","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Protocadherin; Gene silencing; Phosphoprotein; Biology; Neuroscience; Epigenetics; Cell biology; Gene; Genetics; Phosphorylation; Cadherin; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007674748,0.00005843856,0.00004975313,0.00001559364,0.0009066546,0.00004979991,0.0002519198,0.00001115901,0.000007987346],"category_scores_gemma":[0.0001700171,0.00004150952,0.00001837121,0.0001335824,0.0004792855,0.000004926584,0.0001994824,0.00006587141,4.48359e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008060911,"about_ca_system_score_gemma":0.00006230897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005573074,"about_ca_topic_score_gemma":0.00003635898,"domain_scores_codex":[0.9992142,0.0000638118,0.00009635427,0.0002486662,0.0002005181,0.0001764345],"domain_scores_gemma":[0.9996415,0.00003476133,0.00005462527,0.0001883084,0.00003809136,0.00004272502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002590057,0.000006719587,0.0009982086,0.000002116953,0.00000155599,2.073614e-7,0.00003547561,0.001026663,0.9300584,0.0002123402,0.00004119262,0.06759118],"study_design_scores_gemma":[0.0002724086,0.0003999369,0.01183665,0.000001357414,0.000001792487,0.000003986829,0.000246789,0.0002311574,0.1620431,0.008440593,0.8163997,0.0001225843],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874838,0.005718957,0.002866369,0.00189917,0.000130903,0.000685267,0.00001603695,0.000008319537,0.00119118],"genre_scores_gemma":[0.9984037,0.00006411941,0.0007407009,0.0002943739,0.00004758084,0.0001524228,0.000006307796,0.000003635334,0.0002871051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8163585,"threshold_uncertainty_score":0.6973346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183371277904127,"score_gpt":0.301451770972911,"score_spread":0.2896180581938698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}