{"id":"W4308359830","doi":"10.1016/j.jaci.2022.09.041","title":"The upper-airway microbiome as a biomarker of asthma exacerbations despite inhaled corticosteroid treatment","year":2022,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"European Social Fund; European Regional Development Fund; Instituto de Salud Carlos III; Universidad de La Laguna; Agencia Estatal de Investigación; Ministerio de Ciencia, Innovación y Universidades; Ministerio de Ciencia e Innovación; GlaxoSmithKline","keywords":"Asthma; Biomarker; Microbiome; Corticosteroid; Inhaled corticosteroids; Airway; Medicine; Asthma exacerbations; Inhalation; Immunology; Internal medicine; Bioinformatics; Biology; Anesthesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009854265,0.0003032335,0.0006103695,0.0007527049,0.0003912402,0.001254369,0.0002809105,0.0005724342,0.001247147],"category_scores_gemma":[0.003017543,0.000147798,0.0004471797,0.0008275826,0.0003168943,0.0003371501,0.0005473353,0.0004979617,0.0002054985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002492896,"about_ca_system_score_gemma":0.0002264033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001096987,"about_ca_topic_score_gemma":0.001521338,"domain_scores_codex":[0.9989893,0.0003474546,0.00009488495,0.0002051826,0.000223673,0.0001395054],"domain_scores_gemma":[0.9979984,0.000525757,0.0009652561,0.00009329802,0.0002005268,0.0002166949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005128423,0.00004906152,0.986907,0.00006768514,0.0001380532,0.00008012125,0.00009661142,0.0001121171,0.004923514,0.00002594648,0.0001417076,0.00694524],"study_design_scores_gemma":[0.000005462983,0.0001402415,0.997965,0.00002329018,0.00008149875,0.0002767208,0.0001472162,0.0004367353,0.000565898,0.00006604422,0.0002878839,0.000004058245],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959658,0.002840118,0.0002878368,0.00009773336,0.00001713901,0.00001108209,0.000334615,0.000007184088,0.0004384318],"genre_scores_gemma":[0.9989027,0.0003503684,0.0003357821,0.00004418788,0.00002563618,0.00001198122,0.0002432917,0.000002210477,0.00008383429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001254369,"threshold_uncertainty_score":0.005211532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01892836159952786,"score_gpt":0.3135383003627369,"score_spread":0.294609938763209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}