{"id":"W4308365290","doi":"10.1093/genetics/iyac171","title":"The Polo kinase Cdc5 is regulated at multiple levels in the adaptation response to telomere dysfunction","year":2022,"lang":"en","type":"article","venue":"Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; University of Ottawa","funders":"Sorbonne Université; Canadian Institutes of Health Research; Université de Recherche Paris Sciences et Lettres; Institut National Du Cancer; Ligue Contre le Cancer; Canada Research Chairs; Agence Nationale de la Recherche; Equipex; University of Ottawa","keywords":"Biology; Cell cycle; Cell biology; Cell cycle checkpoint; Telomere; Adaptation (eye); DNA damage; G2-M DNA damage checkpoint; Genetics; Cell; Gene; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008046689,0.0001172761,0.00006734607,0.00004310405,0.0004114654,0.0000257216,0.0003168732,0.00006950919,0.00003713665],"category_scores_gemma":[0.0001708188,0.00008927197,0.00005422799,0.0002354388,0.00003196386,0.00000142071,0.0003026181,0.0001019942,0.00001949271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007603052,"about_ca_system_score_gemma":0.00006691194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001963448,"about_ca_topic_score_gemma":0.0003658048,"domain_scores_codex":[0.9985458,0.0004754358,0.0001889373,0.000291577,0.0002588526,0.000239458],"domain_scores_gemma":[0.9991887,0.00006685098,0.00006429289,0.0005878982,0.00004994175,0.00004236135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009626596,0.00003633383,0.0003924606,0.000002063596,0.00001560851,0.000005816064,0.0009489559,0.005006488,0.9827093,0.00002265387,0.005321421,0.00457627],"study_design_scores_gemma":[0.000992374,0.0009596743,0.02350188,0.000003207188,0.00001677247,0.00004066484,0.002593576,0.003213326,0.6400851,0.0001966452,0.3281683,0.0002284618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963542,0.0004153252,0.0004033216,0.002034428,0.0002318083,0.0004269009,0.00005690335,0.00001241217,0.0000646853],"genre_scores_gemma":[0.9957922,0.00002468848,0.0006563537,0.001284154,0.00005871202,0.0001367568,0.00004801426,0.00002275152,0.001976375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3426242,"threshold_uncertainty_score":0.3640405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01987750145458427,"score_gpt":0.2434566075129121,"score_spread":0.2235791060583278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}