{"id":"W4308365290","doi":"10.1093/genetics/iyac171","title":"The Polo kinase Cdc5 is regulated at multiple levels in the adaptation response to telomere dysfunction","year":2022,"lang":"en","type":"article","venue":"Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; University of Ottawa","funders":"Sorbonne Université; Canadian Institutes of Health Research; Université de Recherche Paris Sciences et Lettres; Institut National Du Cancer; Ligue Contre le Cancer; Canada Research Chairs; Agence Nationale de la Recherche; Equipex; University of Ottawa","keywords":"Biology; Cell cycle; Cell biology; Cell cycle checkpoint; Telomere; Adaptation (eye); DNA damage; G2-M DNA damage checkpoint; Genetics; Cell; Gene; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008953518,0.0003768782,0.000167292,0.0003093857,0.0002182633,0.0004455974,0.0001558995,0.000226611,0.0006488956],"category_scores_gemma":[0.00009947101,0.0001542842,0.0001911094,0.0001766552,0.0002332108,0.0002255976,0.0002939003,0.0003613598,0.0001897842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004382551,"about_ca_system_score_gemma":0.000197033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008886848,"about_ca_topic_score_gemma":0.001192072,"domain_scores_codex":[0.999908,0.000009454895,0.000008124694,0.00002966031,0.00002078968,0.00002404805],"domain_scores_gemma":[0.9999329,0.000005602984,0.00001991026,0.000007075801,0.000009971343,0.0000244838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008389469,0.000005987366,0.0006339753,0.00001811172,0.000003157173,0.00005820056,0.000009195363,0.00004938024,0.9981241,0.0001141954,0.00001386265,0.0008858794],"study_design_scores_gemma":[0.000007629902,0.00007532827,0.05153431,0.00001024855,0.00002094164,0.0002917493,0.00005287607,0.0009211251,0.9450402,0.0001780778,0.001860473,0.000006968789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908215,0.004865133,0.002628461,0.0001162392,0.00002644805,0.00001313531,0.0002490967,0.00007079595,0.00120923],"genre_scores_gemma":[0.9975484,0.0006886188,0.0004528618,0.00001910548,0.00000314217,0.000006385657,0.0001590688,0.000006954375,0.001115451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008886848,"threshold_uncertainty_score":0.003179789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01987750145458427,"score_gpt":0.2434566075129121,"score_spread":0.2235791060583278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}