{"id":"W4308374941","doi":"10.1101/2022.11.04.514597","title":"Vitamin B5, a Coenzyme A precursor, rescues TANGO2 deficiency disease-associated defects in <i>Drosophila</i> and human cells","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Coastal Carolina University; Concordia University; Courtois Foundation","keywords":"Drosophila melanogaster; Biology; Disease; Vitamin; Vitamin D and neurology; Phenotype; Endocrinology; Genetics; Medicine; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005913239,0.0008056319,0.0008567519,0.000420942,0.000496077,0.0003461165,0.001040124,0.0003574992,0.00009792265],"category_scores_gemma":[0.001401356,0.0008518273,0.0002768689,0.001116506,0.0003503114,0.0002009485,0.001755279,0.001392381,0.00002864041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002343932,"about_ca_system_score_gemma":0.0003776647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007091034,"about_ca_topic_score_gemma":0.000008179402,"domain_scores_codex":[0.9941193,0.0008370305,0.0007248007,0.002361163,0.0008428784,0.001114861],"domain_scores_gemma":[0.9970307,0.0002923247,0.0005215764,0.001290907,0.0001076161,0.0007569067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009916715,0.001011388,0.01293252,0.0002935255,0.00001095698,0.0007923794,0.00001376372,0.00008360866,0.9796802,0.004596741,0.0004851627,6.053589e-7],"study_design_scores_gemma":[0.002085538,0.0003366875,0.7839705,0.0003679464,0.0003014689,5.120412e-8,0.000003636303,0.0002542803,0.2043741,0.0002071245,0.005996226,0.00210244],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931156,0.00227304,0.000008279609,0.0002016344,0.0009016285,0.001511412,0.001453216,0.000504769,0.00003040757],"genre_scores_gemma":[0.9964952,0.0009496775,0.00005728973,0.001513559,0.0001374929,0.0006789735,7.359207e-7,0.0001523978,0.00001469266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7753061,"threshold_uncertainty_score":0.9993932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01964312198983813,"score_gpt":0.2349944853410931,"score_spread":0.2153513633512549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}