{"id":"W4308375764","doi":"10.1136/jitc-2022-sitc2022.0059","title":"59 DetermaIO (IO score) is associated with efficacy of ICI monotherapy in advanced NSCLC patients: a retrospective BC Cancer study","year":2022,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Internal medicine; Medicine; Cohort; Oncology; Retrospective cohort study; Chemotherapy; Cancer; Combination therapy; PD-L1; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003756883,0.0002766062,0.0005864569,0.0001889445,0.0001553651,0.00002190792,0.0001246113,0.00007742841,0.0000827816],"category_scores_gemma":[0.0001138139,0.0002385805,0.0001009593,0.0005675245,0.000229561,0.000131819,0.00004395828,0.0003531568,5.462539e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005774052,"about_ca_system_score_gemma":0.0004158283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001820858,"about_ca_topic_score_gemma":0.0005619343,"domain_scores_codex":[0.9978923,0.0001186113,0.0005253771,0.0004843517,0.0006442779,0.0003350373],"domain_scores_gemma":[0.9988994,0.00004821502,0.000376072,0.0003320533,0.0001404819,0.000203768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004621529,0.001333211,0.9755773,0.00003832305,0.0005268051,0.00006507057,0.005600662,0.0000797685,0.00917009,0.000004583622,0.0002962001,0.002686453],"study_design_scores_gemma":[0.0173086,0.00252748,0.9713516,0.0003431071,0.0001264156,0.00001107305,0.0008234283,0.00003042572,0.006743569,0.000030685,0.0004316639,0.0002719429],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970393,0.0008200326,0.000001013377,0.0003240594,0.0001811243,0.001363596,0.00007665447,0.00004292203,0.000151356],"genre_scores_gemma":[0.9986551,0.0001193554,0.00004662074,0.0006789641,0.00003016407,0.0001659359,0.00003364853,0.00005012689,0.0002200332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01268707,"threshold_uncertainty_score":0.9729031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01331247988039141,"score_gpt":0.2563421330334675,"score_spread":0.2430296531530761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}