{"id":"W4308375764","doi":"10.1136/jitc-2022-sitc2022.0059","title":"59 DetermaIO (IO score) is associated with efficacy of ICI monotherapy in advanced NSCLC patients: a retrospective BC Cancer study","year":2022,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Internal medicine; Medicine; Cohort; Oncology; Retrospective cohort study; Chemotherapy; Cancer; Combination therapy; PD-L1; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004771474,0.0001637257,0.0002811567,0.0005373793,0.0003332718,0.0005863562,0.0001950916,0.0003065352,0.001196478],"category_scores_gemma":[0.0007915116,0.00018627,0.0005450332,0.0007619649,0.0001973308,0.000210128,0.0002891992,0.0003303835,0.0002896398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003116826,"about_ca_system_score_gemma":0.0002373323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003658087,"about_ca_topic_score_gemma":0.005478309,"domain_scores_codex":[0.9996351,0.00004978895,0.00004336536,0.0001443237,0.00006995007,0.00005745788],"domain_scores_gemma":[0.999335,0.00009853796,0.0002527202,0.00008882539,0.0001106135,0.0001142258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001936846,0.00001065112,0.9981145,0.00001069338,0.00006889323,0.0000335706,0.00001834218,0.00002708114,0.0004607696,0.000009159225,0.0001195507,0.0009332065],"study_design_scores_gemma":[0.000008004905,0.00007112091,0.998809,0.000004248041,0.00006362452,0.000196887,0.00005244513,0.0001552322,0.0001664841,0.00001657029,0.0004530756,0.000003390945],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974311,0.0005090265,0.0001446401,0.00002151688,0.000008672728,0.00001783877,0.001161275,0.000004169392,0.0007017244],"genre_scores_gemma":[0.9986539,0.00009175871,0.00007606912,0.00002970184,0.000007865078,0.00001572205,0.0009759261,0.000003101585,0.0001459493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003658087,"threshold_uncertainty_score":0.007273614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01331247988039141,"score_gpt":0.2563421330334675,"score_spread":0.2430296531530761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}