{"id":"W4308385775","doi":"10.1136/jitc-2022-sitc2022.0750","title":"750 TWT-101: a first-in-clinic, phase 1/2 study of CFI-402411, a hematopoietic progenitor kinase-1 (HPK1) inhibitor, as a single agent and in combination with pembrolizumab in subjects with advanced solid malignancies","year":2022,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ottawa Hospital","funders":"","keywords":"Pembrolizumab; Medicine; Internal medicine; Gastroenterology; Oncology; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002908251,0.0002623039,0.0003918128,0.000179952,0.00009411591,0.00004198711,0.0001169683,0.0000870669,0.000003466854],"category_scores_gemma":[0.0001552922,0.0002548622,0.00003205127,0.0002749412,0.000176027,0.00001907398,0.0001405042,0.0001827946,3.911236e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009814185,"about_ca_system_score_gemma":0.0003648583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003756802,"about_ca_topic_score_gemma":0.003842453,"domain_scores_codex":[0.998261,0.00008602057,0.0004914268,0.0005480397,0.0002875862,0.0003259387],"domain_scores_gemma":[0.9991816,0.00003976293,0.0002367565,0.0002861742,0.00006719393,0.0001885228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009307068,0.014243,0.3700204,0.001040106,0.0002354843,0.001773718,0.01227078,0.006863162,0.5825595,0.0001322288,0.0003131748,0.001241349],"study_design_scores_gemma":[0.06886103,0.03769002,0.231803,0.001115638,0.0002238988,0.0008292262,0.0169227,0.0004416007,0.6366526,0.0007180544,0.002831288,0.001910921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972238,0.001387884,0.000002379501,0.0001460674,0.00008508072,0.001059902,0.00002470437,0.000008676064,0.00006149092],"genre_scores_gemma":[0.9991959,0.0001353193,0.0001562434,0.00008100616,0.0000291288,0.0002722998,0.00004922753,0.00003876441,0.00004216333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1382174,"threshold_uncertainty_score":0.9999903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01073260727766131,"score_gpt":0.2477301152551453,"score_spread":0.236997507977484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}