{"id":"W4308385775","doi":"10.1136/jitc-2022-sitc2022.0750","title":"750 TWT-101: a first-in-clinic, phase 1/2 study of CFI-402411, a hematopoietic progenitor kinase-1 (HPK1) inhibitor, as a single agent and in combination with pembrolizumab in subjects with advanced solid malignancies","year":2022,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ottawa Hospital","funders":"","keywords":"Pembrolizumab; Medicine; Internal medicine; Gastroenterology; Oncology; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001397347,0.002093846,0.001687224,0.000717882,0.0007460933,0.001570763,0.001431613,0.002449277,0.006620057],"category_scores_gemma":[0.0005219143,0.0009182255,0.001234369,0.0004562361,0.001068297,0.001091339,0.0003423432,0.005715627,0.002473455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001959166,"about_ca_system_score_gemma":0.00283185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002603728,"about_ca_topic_score_gemma":0.009569752,"domain_scores_codex":[0.9994463,0.0001947575,0.00002020476,0.00009764932,0.000076942,0.0001640193],"domain_scores_gemma":[0.9994426,0.00004891954,0.00005677911,0.0000336833,0.0000419832,0.0003759678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"nonrandomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2227568,0.2932779,0.005025026,0.001294045,0.001557229,0.0006701524,0.000474895,0.005894072,0.260356,0.001169045,0.03173095,0.1757938],"study_design_scores_gemma":[0.2854302,0.6734461,0.009808149,0.00005825221,0.0004521546,0.0005156843,0.00009896795,0.001800607,0.01759556,0.0004166003,0.01030061,0.00007710043],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9637858,0.003573238,0.00185822,0.001843605,0.0004760493,0.01061314,0.006322716,0.0005868185,0.01094046],"genre_scores_gemma":[0.9477923,0.003592833,0.006439183,0.004676518,0.000348705,0.01032555,0.01011127,0.0001717081,0.01654195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006620057,"threshold_uncertainty_score":0.02214628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01073260727766131,"score_gpt":0.2477301152551453,"score_spread":0.236997507977484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}