{"id":"W4308395446","doi":"10.1136/jitc-2022-sitc2022.1196","title":"1196 Streamlining T cell engager development with a diverse panel of fully human CD3-binding antibodies, bispecific engineering technology, and an integrated discovery engine","year":2022,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"AbCellera (Canada)","funders":"","keywords":"CD3; Bispecific antibody; Antibody; Flow cytometry; T cell; Chemistry; Molecular biology; Cancer research; Biology; Computational biology; Monoclonal antibody; Antigen; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005275033,0.0004172175,0.0002749845,0.0003616911,0.0001569562,0.0006132407,0.0003320179,0.0002993032,0.004342549],"category_scores_gemma":[0.000271944,0.0002039366,0.0003095277,0.0002056216,0.0001707796,0.0003309336,0.0004008439,0.0007491322,0.002362565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004171336,"about_ca_system_score_gemma":0.0003465495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004614123,"about_ca_topic_score_gemma":0.001011442,"domain_scores_codex":[0.9997076,0.00003542174,0.00002705543,0.00005378574,0.0001257446,0.00005039675],"domain_scores_gemma":[0.9998972,0.00002210406,0.00001968396,0.00001289325,0.00002697796,0.00002115122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007259957,0.00008087853,0.0003155612,0.00005715359,0.00000903191,0.00005028005,0.00001769209,0.0006698275,0.9727423,0.001047484,0.001435863,0.02350131],"study_design_scores_gemma":[0.00002266094,0.0002239993,0.0005860035,0.000007816844,0.00000989781,0.0001999913,0.00001283301,0.006313366,0.9738327,0.0002904356,0.01849017,0.00001025178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4423218,0.002272271,0.5256919,0.001011317,0.0002569558,0.000972382,0.0022101,0.00488562,0.02037768],"genre_scores_gemma":[0.4932708,0.001733997,0.4851539,0.0007344986,0.00006911504,0.0007451245,0.00270529,0.0004207429,0.01516657],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004342549,"threshold_uncertainty_score":0.01452732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03023338062932235,"score_gpt":0.2584438281147855,"score_spread":0.2282104474854632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}