{"id":"W4308398717","doi":"10.1136/jitc-2022-sitc2022.0261","title":"261 Evidence for durable anti-tumor responses by TAC-T cells in preclinical models of solid tumors","year":2022,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Cancer research; Flow cytometry; T cell; Antigen; Bone marrow; Immune system; Cytotoxic T cell; Biology; Molecular biology; Immunology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002464425,0.0002384065,0.0007147031,0.0002265157,0.0001590301,0.00003086294,0.000248128,0.00009985931,0.000147333],"category_scores_gemma":[0.001502453,0.0002354737,0.0001732385,0.0003326839,0.000428441,0.0002316718,0.000150282,0.0005358509,0.000002796519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001544705,"about_ca_system_score_gemma":0.001020502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003036767,"about_ca_topic_score_gemma":0.00001477549,"domain_scores_codex":[0.9969893,0.0002706023,0.0008448795,0.0005830054,0.0007638278,0.0005483567],"domain_scores_gemma":[0.9977683,0.0007819699,0.0002453344,0.0005161467,0.0001336667,0.0005545891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002035638,0.0003192227,0.00874896,0.0005342829,0.00006853916,0.0001632771,0.0004896127,0.001621832,0.9749479,0.00008341233,0.01067023,0.0003171061],"study_design_scores_gemma":[0.004345729,0.002032791,0.0233903,0.0008994204,0.0001302765,0.0004335407,0.0006831558,0.009260139,0.9429799,0.002491175,0.01281454,0.0005390721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945053,0.002025544,0.00003128315,0.001634986,0.000171851,0.001221512,0.0002162598,0.00004125645,0.0001519715],"genre_scores_gemma":[0.993507,0.0002996204,0.0006927612,0.0004313602,0.00007636629,0.0001841944,0.00002924933,0.00005812768,0.004721317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03196803,"threshold_uncertainty_score":0.960234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09622014376030799,"score_gpt":0.3660636532016021,"score_spread":0.2698435094412941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}