{"id":"W4308398717","doi":"10.1136/jitc-2022-sitc2022.0261","title":"261 Evidence for durable anti-tumor responses by TAC-T cells in preclinical models of solid tumors","year":2022,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Cancer research; Flow cytometry; T cell; Antigen; Bone marrow; Immune system; Cytotoxic T cell; Biology; Molecular biology; Immunology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003030869,0.000450033,0.0003576424,0.0003280693,0.0001778709,0.0003647764,0.0002392074,0.0004112255,0.003385001],"category_scores_gemma":[0.0002088269,0.0001454904,0.0003176405,0.0001834271,0.0002892855,0.0002305568,0.0001141861,0.001549288,0.001198777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002145015,"about_ca_system_score_gemma":0.0002863661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005199041,"about_ca_topic_score_gemma":0.0005768751,"domain_scores_codex":[0.9997477,0.00004274475,0.0000225115,0.00005230542,0.00006944359,0.0000652473],"domain_scores_gemma":[0.9997484,0.00003782173,0.00006278577,0.00004108604,0.00004409617,0.0000657414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001428109,0.0009315668,0.0004340037,0.0001253781,0.00001955954,0.0001206391,0.00003915758,0.0002371584,0.9896912,0.0001818164,0.0008388424,0.005952386],"study_design_scores_gemma":[0.0002568985,0.01679034,0.006478998,0.00003409955,0.00007569748,0.001027522,0.00008167585,0.001664706,0.9645748,0.0001920649,0.008809433,0.00001378214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805846,0.003652189,0.004717647,0.0004323013,0.0002268268,0.0002152117,0.002122929,0.000376988,0.007671359],"genre_scores_gemma":[0.9840747,0.001702028,0.002679863,0.0003152142,0.00008267493,0.0002269401,0.00352703,0.00008007477,0.007311456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003385001,"threshold_uncertainty_score":0.01132399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09622014376030799,"score_gpt":0.3660636532016021,"score_spread":0.2698435094412941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}