{"id":"W4308399396","doi":"10.1136/jitc-2022-sitc2022.0558","title":"558 CTX130 allogeneic CRISPR-Cas9–engineered chimeric antigen receptor (CAR) T cells in patients with advanced clear cell renal cell carcinoma: Results from the phase 1 COBALT-RCC study","year":2022,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Renal cell carcinoma; Fludarabine; Medicine; Clear cell renal cell carcinoma; Internal medicine; Refractory (planetary science); Chimeric antigen receptor; Oncology; Gastroenterology; Cyclophosphamide; Cancer research; Immunotherapy; Chemotherapy; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005973821,0.0003598443,0.0006994118,0.0001080091,0.0001861004,0.0005120121,0.0002340271,0.0003559987,0.001107798],"category_scores_gemma":[0.000258267,0.0001396843,0.000545935,0.0001727429,0.000269265,0.0002323151,0.0001437809,0.000823627,0.0003149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006885562,"about_ca_system_score_gemma":0.0007207477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001648552,"about_ca_topic_score_gemma":0.003364159,"domain_scores_codex":[0.9998372,0.00005185568,0.000009403519,0.00003742701,0.00003076666,0.00003332213],"domain_scores_gemma":[0.9997697,0.00004043188,0.00004317423,0.00002140476,0.0000276732,0.00009762598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3340463,0.0246348,0.1174477,0.0009689358,0.002594772,0.0005869261,0.0006652244,0.008614424,0.181475,0.0004981194,0.01703826,0.3114296],"study_design_scores_gemma":[0.198688,0.4401667,0.2935479,0.0001019404,0.002904129,0.001208694,0.0002469651,0.008079917,0.03081806,0.0004499429,0.02369869,0.00008919492],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957711,0.001606206,0.0002389578,0.0002317081,0.0000321668,0.0002206254,0.0006107881,0.0000371854,0.001251294],"genre_scores_gemma":[0.9965973,0.0006320971,0.0002890032,0.0002746932,0.00003436556,0.0001047016,0.001408083,0.00001108565,0.0006486274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001648552,"threshold_uncertainty_score":0.004995823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01358275220468149,"score_gpt":0.2454665609501217,"score_spread":0.2318838087454402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}