{"id":"W4308399396","doi":"10.1136/jitc-2022-sitc2022.0558","title":"558 CTX130 allogeneic CRISPR-Cas9–engineered chimeric antigen receptor (CAR) T cells in patients with advanced clear cell renal cell carcinoma: Results from the phase 1 COBALT-RCC study","year":2022,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Renal cell carcinoma; Fludarabine; Medicine; Clear cell renal cell carcinoma; Internal medicine; Refractory (planetary science); Chimeric antigen receptor; Oncology; Gastroenterology; Cyclophosphamide; Cancer research; Immunotherapy; Chemotherapy; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009349402,0.0005333969,0.0007176059,0.0002244465,0.0004078227,0.00008895021,0.0004537521,0.0001341786,0.0002700058],"category_scores_gemma":[0.0001385236,0.0004197007,0.0001391992,0.0007407345,0.0002822953,0.0001600574,0.000246929,0.001097583,0.00002664449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003071182,"about_ca_system_score_gemma":0.0005493125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001340551,"about_ca_topic_score_gemma":0.00008317419,"domain_scores_codex":[0.9953815,0.0004752024,0.0008385031,0.001071632,0.001405224,0.0008279389],"domain_scores_gemma":[0.9974027,0.0002005135,0.0003199971,0.00111413,0.0001668693,0.000795816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01093347,0.004245551,0.1321316,0.00009595619,0.0002380181,0.0004615535,0.006407877,0.002061876,0.8343323,0.00000152465,0.007815538,0.001274739],"study_design_scores_gemma":[0.04791901,0.008442093,0.6575248,0.0000943995,0.0002792479,0.00002184947,0.004178441,0.0002824638,0.2592193,0.0000148038,0.0210967,0.0009269435],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948153,0.000734407,0.000002793234,0.0003903091,0.000374313,0.002635236,0.0006467216,0.00008284593,0.000318074],"genre_scores_gemma":[0.9971241,0.00007966896,0.0004504296,0.0003132138,0.0001818991,0.0001128095,0.000656009,0.0001351318,0.000946755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5751131,"threshold_uncertainty_score":0.9998255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01358275220468149,"score_gpt":0.2454665609501217,"score_spread":0.2318838087454402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}