{"id":"W4308400784","doi":"10.1136/jitc-2022-sitc2022.1028","title":"1028 IL-12 and IL-27 upregulate CD39 expression on CD8<sup>+</sup> T-cells and differentially affect CD39<sup>+</sup>CD8<sup>+</sup> T-cell effector function","year":2022,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Cytotoxic T cell; CD8; CD28; Biology; T cell; Molecular biology; IL-2 receptor; Tumor-infiltrating lymphocytes; Flow cytometry; Interleukin 21; Cancer research; Immune system; Cell biology; Chemistry; Immunology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006666304,0.0002423599,0.0001816836,0.0001383126,0.00007802765,0.0002447041,0.0001047448,0.000236845,0.003737992],"category_scores_gemma":[0.00007287873,0.00008906301,0.0001508407,0.0001017129,0.0001642324,0.0001239836,0.0001050465,0.0005707899,0.001015649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001146713,"about_ca_system_score_gemma":0.0001529219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001515736,"about_ca_topic_score_gemma":0.0003382778,"domain_scores_codex":[0.9998499,0.00002325666,0.00001808198,0.0000227992,0.00003150676,0.00005440087],"domain_scores_gemma":[0.999934,0.00001163458,0.00001434495,0.00000709558,0.000006014503,0.00002706641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008181819,0.0001665281,0.0004689615,0.00004764718,0.000003978826,0.0001298058,0.00001657043,0.00006297458,0.9959948,0.00008398409,0.0001431049,0.002063354],"study_design_scores_gemma":[0.000200206,0.002405565,0.01494605,0.00001718848,0.0000321664,0.0005399205,0.0001483472,0.001358945,0.9741439,0.0001599775,0.006037214,0.00001052672],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9954497,0.0007502108,0.0007473565,0.0001122982,0.00006555219,0.00002695688,0.0003901351,0.00005134138,0.002406474],"genre_scores_gemma":[0.9932083,0.0004281187,0.001262496,0.0001381605,0.00002544178,0.00008371583,0.0006353411,0.00001763204,0.004200712],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.003737992,"threshold_uncertainty_score":0.01250482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01338454817618056,"score_gpt":0.233697738298737,"score_spread":0.2203131901225564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}