{"id":"W4308400784","doi":"10.1136/jitc-2022-sitc2022.1028","title":"1028 IL-12 and IL-27 upregulate CD39 expression on CD8+ T-cells and differentially affect CD39+CD8+ T-cell effector function","year":2022,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Cytotoxic T cell; CD8; CD28; Biology; T cell; Molecular biology; IL-2 receptor; Tumor-infiltrating lymphocytes; Flow cytometry; Interleukin 21; Cancer research; Immune system; Cell biology; Chemistry; Immunology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0009138109,0.001284852,0.001377697,0.0006822167,0.001184433,0.0004018551,0.0003449605,0.0004668061,0.0002397191],"category_scores_gemma":[0.0003567061,0.001120035,0.0003983155,0.0004695657,0.0007419256,0.0005239389,0.0006102758,0.001482572,0.0001166951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003275863,"about_ca_system_score_gemma":0.0004302986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000179592,"about_ca_topic_score_gemma":0.000009411534,"domain_scores_codex":[0.9925383,0.0009159364,0.0009602425,0.002065578,0.00193989,0.001580109],"domain_scores_gemma":[0.9950315,0.0005296106,0.0003804007,0.001215199,0.0001544669,0.002688824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007811361,0.003180199,0.03367142,0.003613657,0.001497127,0.002797081,0.003505814,0.01187159,0.8934772,0.0001440049,0.03083877,0.007591754],"study_design_scores_gemma":[0.04299467,0.02082916,0.1309927,0.003205625,0.003200772,0.002593105,0.002084889,0.03456129,0.7084825,0.001199368,0.04562728,0.004228672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939314,0.0009523386,0.00003037664,0.0007822777,0.0003684525,0.002443896,0.0004494274,0.0003449575,0.0006968409],"genre_scores_gemma":[0.9929787,0.0004284444,0.0003354123,0.000633559,0.0004770512,0.000269081,0.0004307174,0.0002566187,0.004190417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1849947,"threshold_uncertainty_score":0.9999903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01338454817618056,"score_gpt":0.233697738298737,"score_spread":0.2203131901225564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}