{"id":"W4308415196","doi":"10.3389/fimmu.2022.1029269","title":"Oncolytic virus driven T-cell-based combination immunotherapy platform for colorectal cancer","year":2022,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Interface Biologics (Canada); Ottawa Hospital; University of Ottawa","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Terry Fox Research Institute; Canadian Cancer Society","keywords":"Oncolytic virus; Colorectal cancer; Cancer research; Tumor microenvironment; Medicine; Immune system; Immunotherapy; Cancer; Immunogenic cell death; Cancer cell; CD8; Cytotoxic T cell; Immunology; Biology; In vitro; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008089887,0.0003077225,0.0002425532,0.0001676722,0.00007700954,0.000241464,0.000172305,0.0003024112,0.0007626605],"category_scores_gemma":[0.00006774369,0.0001002872,0.0001897577,0.0001051354,0.0001002971,0.0001679095,0.0001842515,0.0005520073,0.0002824372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002376373,"about_ca_system_score_gemma":0.0001807358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003491259,"about_ca_topic_score_gemma":0.0005392231,"domain_scores_codex":[0.9999025,0.00001215064,0.000005874163,0.00002265946,0.00003003041,0.00002678444],"domain_scores_gemma":[0.9999764,0.000002747199,0.000006630617,0.000003543246,0.000003839165,0.000006799072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000123279,0.00005837214,0.00009994057,0.00006154313,0.000009007759,0.00004349158,0.00001060071,0.0003868637,0.9933493,0.000151028,0.0001831434,0.005523503],"study_design_scores_gemma":[0.00006013407,0.001498687,0.001196884,0.000008175788,0.00005029366,0.0005318494,0.00001338288,0.005811308,0.9786497,0.0001007761,0.01206819,0.00001065578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680397,0.006867728,0.01989325,0.0002077031,0.0001457997,0.0002242523,0.0005394231,0.0003360156,0.003746112],"genre_scores_gemma":[0.9872938,0.001601446,0.007743432,0.00007988922,0.00001816533,0.0001275242,0.0004236868,0.00002216009,0.00269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007626605,"threshold_uncertainty_score":0.002551377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01721192061402348,"score_gpt":0.2975827241361198,"score_spread":0.2803708035220963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}