{"id":"W4308426407","doi":"10.1016/s2213-8587(22)00277-7","title":"Efficacy and safety of setmelanotide, a melanocortin-4 receptor agonist, in patients with Bardet-Biedl syndrome and Alström syndrome: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial with an open-label period","year":2022,"lang":"en","type":"article","venue":"The Lancet Diabetes & Endocrinology","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":182,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institutes of Health","keywords":"Medicine; Placebo; Pediatrics; Internal medicine; Clinical endpoint; Randomized controlled trial; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004155416,0.0003551063,0.001073044,0.00008939752,0.0002534806,0.00005405532,0.0005618359,0.00006743689,0.00007720749],"category_scores_gemma":[0.0000873849,0.0002421906,0.00004123214,0.0001471056,0.0003679528,0.00001594253,0.0005293191,0.0002448331,0.000001418462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002250622,"about_ca_system_score_gemma":0.0001653688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003714245,"about_ca_topic_score_gemma":0.00004996185,"domain_scores_codex":[0.9972186,0.0005498205,0.0005079459,0.0006571473,0.0002233816,0.0008431023],"domain_scores_gemma":[0.9986794,0.0001272441,0.0003308668,0.0006121772,0.00006634594,0.0001839428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.973164,0.001822317,0.02018214,0.000044234,0.0006172063,0.00004185793,0.0001416476,0.00005877252,0.002999437,0.00002147183,0.0001152428,0.0007917195],"study_design_scores_gemma":[0.9726868,0.013826,0.01031874,0.00002993692,0.0003173728,0.00008487748,0.0002050864,0.00004719194,0.0009845441,0.00001220508,0.00112705,0.0003601925],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992862,0.000983572,0.000004081109,0.000304666,0.00008993998,0.005273035,0.0003570475,0.00001628273,0.0001093518],"genre_scores_gemma":[0.9973458,0.0001139084,0.0003137549,0.0002302338,0.00004719055,0.001273259,0.0005285571,0.00004332307,0.0001039872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01200368,"threshold_uncertainty_score":0.9876246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01780379819125191,"score_gpt":0.2747634658659727,"score_spread":0.2569596676747208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}