{"id":"W4308426407","doi":"10.1016/s2213-8587(22)00277-7","title":"Efficacy and safety of setmelanotide, a melanocortin-4 receptor agonist, in patients with Bardet-Biedl syndrome and Alström syndrome: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial with an open-label period","year":2022,"lang":"en","type":"article","venue":"The Lancet Diabetes & Endocrinology","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":182,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institutes of Health","keywords":"Medicine; Placebo; Pediatrics; Internal medicine; Clinical endpoint; Randomized controlled trial; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001839799,0.001885476,0.004053454,0.0005027971,0.0005886691,0.001338257,0.0009275246,0.003121192,0.005750331],"category_scores_gemma":[0.001874193,0.0009440172,0.002842415,0.0003995723,0.001792974,0.00198348,0.0005093665,0.003900221,0.0009576711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009372432,"about_ca_system_score_gemma":0.00089613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008764897,"about_ca_topic_score_gemma":0.001403803,"domain_scores_codex":[0.999285,0.0003176139,0.00005975971,0.0001473676,0.00006001381,0.0001301489],"domain_scores_gemma":[0.9988456,0.0002969413,0.0001899589,0.00009013254,0.00007030839,0.0005072062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9864882,0.003381716,0.0004634549,0.000227404,0.0004608077,0.00003311242,0.00003666284,0.0001670455,0.00240381,0.00004058555,0.0002360702,0.006061173],"study_design_scores_gemma":[0.9229877,0.0733272,0.002473631,0.0000201999,0.0002838672,0.00003543425,0.00002414239,0.0002568992,0.0002831413,0.00009117543,0.0001925125,0.00002404946],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926907,0.003770115,0.0003263921,0.0004387893,0.0003422835,0.0008134567,0.0005671041,0.00007042044,0.0009807816],"genre_scores_gemma":[0.9931599,0.001465071,0.0006198094,0.0008878869,0.0003493036,0.001252051,0.0008612234,0.00002092213,0.001383902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005750331,"threshold_uncertainty_score":0.01923674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01780379819125191,"score_gpt":0.2747634658659727,"score_spread":0.2569596676747208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}