{"id":"W4308432482","doi":"10.1016/j.lungcan.2022.11.004","title":"Patient-reported outcomes from the randomized phase 3 CROWN study of first-line lorlatinib versus crizotinib in advanced ALK-positive non-small cell lung cancer","year":2022,"lang":"en","type":"article","venue":"Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Pfizer","keywords":"Crizotinib; Medicine; Lung cancer; Nausea; Internal medicine; Quality of life (healthcare); ALK inhibitor; Oncology; Nursing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002281289,0.0003529548,0.00107325,0.0001283628,0.0003026862,0.00001888894,0.0001748472,0.00005363415,0.001488507],"category_scores_gemma":[0.0001132037,0.0002453853,0.0002552858,0.0005105757,0.00008051431,0.00009624384,0.0001421969,0.0003813469,9.055489e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008898286,"about_ca_system_score_gemma":0.0005123926,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02677091,"about_ca_topic_score_gemma":0.008638781,"domain_scores_codex":[0.9973383,0.0002279642,0.0009176143,0.0005744918,0.0005633855,0.000378248],"domain_scores_gemma":[0.9975278,0.0009588157,0.0006335441,0.0005516968,0.0002143708,0.000113813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2292075,0.008185253,0.6418778,0.000177962,0.007702257,0.0003345327,0.07593995,0.02282652,0.0006264787,0.000009714109,0.002451024,0.01066094],"study_design_scores_gemma":[0.900537,0.001915276,0.06575382,0.0003531648,0.008257173,0.000002286905,0.01143733,0.008668427,0.001369146,0.00001170696,0.00119176,0.0005029679],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834344,0.004932904,0.00006242313,0.001204139,0.001714758,0.006446377,0.0007714849,0.00004446823,0.001389001],"genre_scores_gemma":[0.9920279,0.0002460382,0.000125016,0.0004910494,0.0001146955,0.00594053,0.0002425189,0.00006012715,0.0007521538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6713294,"threshold_uncertainty_score":0.9999998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01798761460819827,"score_gpt":0.3551372383528579,"score_spread":0.3371496237446596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}