{"id":"W4308445587","doi":"10.21203/rs.3.rs-2114208/v1","title":"Human GLP1R variants affecting GLP1R cell surface expression contribute to impaired glucose control and increased adiposity","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Nautical Research Society; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institutes of Health; National Natural Science Foundation of China; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Medical Research Council; Centre National de la Recherche Scientifique; CHIST-ERA; European Commission","keywords":"Internal medicine; Endocrinology; Chemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002218331,0.0005560404,0.0004018498,0.0002475013,0.0001455519,0.0005968499,0.0002101398,0.000761122,0.007769788],"category_scores_gemma":[0.0004892701,0.0001849735,0.0003603834,0.0002514264,0.0003226939,0.000162399,0.0002490814,0.0009382465,0.001462501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001215907,"about_ca_system_score_gemma":0.0001067741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003308579,"about_ca_topic_score_gemma":0.0001705063,"domain_scores_codex":[0.9998807,0.000027212,0.000009126473,0.00003741857,0.00002578807,0.00001971828],"domain_scores_gemma":[0.9998322,0.00006388235,0.00004508406,0.00002075339,0.00001123523,0.00002688815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007307146,0.0002839452,0.008223861,0.0001721158,0.0002556957,0.004200303,0.0001537378,0.001127837,0.9448543,0.003562024,0.004669625,0.02518949],"study_design_scores_gemma":[0.002224011,0.001914634,0.1851603,0.0001416249,0.001139368,0.02756552,0.0006357779,0.01588228,0.6938331,0.01817228,0.05320812,0.0001230425],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793953,0.0016752,0.009928162,0.001186098,0.0004967694,0.00002452575,0.003145905,0.0002499347,0.003898039],"genre_scores_gemma":[0.9838182,0.0009494697,0.003300042,0.000388885,0.000216359,0.00002746056,0.003006721,0.0002142267,0.008078637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007769788,"threshold_uncertainty_score":0.02599257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03497217088387177,"score_gpt":0.3573177008040586,"score_spread":0.3223455299201868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}