{"id":"W4308483942","doi":"10.1080/00207454.2022.2142579","title":"Anatomical location of injected microglia in different activation states and time course of injury determines survival of retinal ganglion cells after optic nerve crush","year":2022,"lang":"en","type":"article","venue":"International Journal of Neuroscience","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Glaucoma Research Society of Canada","keywords":"Microglia; Optic nerve; Neuroprotection; Retina; Retinal ganglion cell; Proinflammatory cytokine; Nerve injury; Crush injury; Retinal; Minocycline; Chemistry; Neurotrophin; Medicine; Neuroscience; Cell biology; Pathology; Pharmacology; Anatomy; Biology; Ophthalmology; Inflammation; Immunology; Internal medicine; Surgery; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009529862,0.0002314396,0.0001784657,0.000239217,0.000131322,0.0002754965,0.00009334315,0.0002840821,0.00127284],"category_scores_gemma":[0.0001027569,0.0001078046,0.0002005929,0.00009967716,0.0002500706,0.0001697341,0.0001102776,0.0004676937,0.0002563435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002177683,"about_ca_system_score_gemma":0.000223299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007926947,"about_ca_topic_score_gemma":0.001362053,"domain_scores_codex":[0.9998537,0.00001071618,0.00001162519,0.00002978969,0.00002786634,0.00006619983],"domain_scores_gemma":[0.9998673,0.00002011973,0.0000482235,0.000008144595,0.00001745827,0.00003872691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000576152,0.00006660148,0.001076296,0.00003803787,0.00000428053,0.0001020819,0.00005167909,0.00003367675,0.9970474,0.00003810624,0.00002335144,0.0009423424],"study_design_scores_gemma":[0.00002270473,0.001646019,0.03280798,0.00001999292,0.00003453406,0.0002877593,0.0002351765,0.0004117141,0.9639981,0.00005267528,0.0004745747,0.00000867421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970092,0.0009471924,0.0008680155,0.00003275169,0.00002348425,0.00002221314,0.0001666823,0.00002555995,0.0009047694],"genre_scores_gemma":[0.9958611,0.0007180706,0.001285901,0.00003254773,0.00001512366,0.00006329975,0.0001822967,0.00001007595,0.001831641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00127284,"threshold_uncertainty_score":0.004258037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01388618007787233,"score_gpt":0.2695736238585189,"score_spread":0.2556874437806465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}