{"id":"W4308506817","doi":"10.3390/cancers14225478","title":"Prostate Cancer Cells Are Sensitive to Lysosomotropic Agent Siramesine through Generation Reactive Oxygen Species and in Combination with Tyrosine Kinase Inhibitors","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Manitoba; CancerCare Manitoba","funders":"University of Manitoba; Natural Sciences and Engineering Research Council of Canada; CancerCare Manitoba Foundation","keywords":"Lapatinib; Programmed cell death; Cancer cell; Cancer research; Prostate cancer; Apoptosis; Tyrosine kinase; Reactive oxygen species; Pharmacology; Cancer; Chemistry; Medicine; Biology; Cell biology; Signal transduction; Biochemistry; Internal medicine; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001106064,0.0003535623,0.0003864497,0.0002508702,0.0001479551,0.0002134312,0.0001579071,0.0002426066,0.001330436],"category_scores_gemma":[0.0001101677,0.0001219284,0.0004118875,0.0002165172,0.0001258376,0.0001609373,0.000170857,0.0005290313,0.0003192584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001539558,"about_ca_system_score_gemma":0.0001669292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004367424,"about_ca_topic_score_gemma":0.0008923477,"domain_scores_codex":[0.9998145,0.0000283015,0.00001648713,0.00002498723,0.00008466488,0.00003123571],"domain_scores_gemma":[0.9999001,0.000014367,0.00003401806,0.00001184352,0.00001844214,0.00002119615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002019044,0.00008710002,0.0006476487,0.0001725592,0.00003551146,0.0002208439,0.00002839283,0.0001595501,0.9947003,0.00006642658,0.0002834715,0.003396315],"study_design_scores_gemma":[0.00003329232,0.001389712,0.0088998,0.00001252856,0.00005154665,0.001035959,0.00005145431,0.000726141,0.9817144,0.00004297291,0.006032126,0.00001014934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784793,0.01253519,0.002725976,0.0003258047,0.000132444,0.00009142269,0.0008131717,0.0002019879,0.004694817],"genre_scores_gemma":[0.9910964,0.00385985,0.00150859,0.0001258086,0.00002571413,0.00006431399,0.0009662931,0.00001208442,0.002341017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001330436,"threshold_uncertainty_score":0.004450738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134336556890604,"score_gpt":0.2323011735001695,"score_spread":0.2209578079312635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}