{"id":"W4308507704","doi":"10.1128/aac.00938-22","title":"Molecular Characterization of Clinical Rel Mutations and Consequences for Resistance Expression and Fitness in Staphylococcus aureus","year":2022,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Canadian Institutes of Health Research; European Society of Clinical Microbiology and Infectious Diseases; Government of Canada","keywords":"Biology; Stringent response; Antibiotics; Microbiology; Multidrug tolerance; Mutant; Virulence; Bacteria; Hydrolase; Mutation; Genetics; Antibiotic resistance; Staphylococcus aureus; Enzyme; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001514473,0.0002483842,0.0001686618,0.0004039024,0.0001409555,0.0001884911,0.0001839369,0.0003456514,0.002176374],"category_scores_gemma":[0.0005138487,0.0001235475,0.0002237195,0.0001901595,0.0002710603,0.0001104489,0.0001705095,0.0002915968,0.0003943692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001621174,"about_ca_system_score_gemma":0.0001377288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007756179,"about_ca_topic_score_gemma":0.0007852026,"domain_scores_codex":[0.9998096,0.00003209748,0.00002726995,0.00004386001,0.00004788398,0.00003934793],"domain_scores_gemma":[0.9997185,0.00006877985,0.0000817936,0.00001742756,0.00004053481,0.0000730208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004907169,0.0002029235,0.01555019,0.0000545105,0.00001608599,0.002059144,0.0001035061,0.0001189893,0.9778599,0.0001583664,0.0001012619,0.003284424],"study_design_scores_gemma":[0.0001393742,0.004920179,0.5264255,0.00006170104,0.0001019067,0.03556163,0.0009409465,0.002903221,0.4249794,0.000337004,0.003581449,0.00004764655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987308,0.0001468909,0.000302007,0.00003962683,0.000006900132,0.00002243364,0.0002403128,0.000008736387,0.0005023059],"genre_scores_gemma":[0.9986016,0.00008204907,0.0003737637,0.00004500422,0.000004695096,0.00001280425,0.0003419256,0.000009956758,0.0005283409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002176374,"threshold_uncertainty_score":0.007280707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02507696318149821,"score_gpt":0.3251207339025566,"score_spread":0.3000437707210584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}