{"id":"W4308510590","doi":"10.1016/j.immuni.2022.10.014","title":"Innate immune mechanisms of mRNA vaccines","year":2022,"lang":"en","type":"review","venue":"Immunity","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":463,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Szegedi Tudományegyetem; National Institute of Allergy and Infectious Diseases; Vlaamse regering; Universiteit Gent; Knut och Alice Wallenbergs Stiftelse; Bijzonder Onderzoeksfonds UGent; University of California, Los Angeles; Vetenskapsrådet; University of Pennsylvania","keywords":"Innate immune system; Immunogenicity; Biology; Context (archaeology); Adjuvant; Immune system; Immunity; Messenger RNA; Immunology; Virology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003144598,0.0002907172,0.0008150399,0.0001004595,0.00009703171,0.00001148867,0.0007928089,0.0002502649,0.0005017021],"category_scores_gemma":[0.00007944669,0.0002571436,0.0005414378,0.0001629922,0.00003334703,0.000002322642,0.0007152594,0.0003514165,0.00002479113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000196511,"about_ca_system_score_gemma":0.0001924551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001684301,"about_ca_topic_score_gemma":0.00001114818,"domain_scores_codex":[0.9986273,0.0002803904,0.0005181849,0.0002588802,0.0001210984,0.0001941139],"domain_scores_gemma":[0.9985964,0.00002659645,0.0003789135,0.0009001587,0.00006414176,0.00003384187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003554655,0.0001466587,0.000001395896,0.003188714,0.0005792796,0.000006831611,0.00002657219,0.000001427294,0.01396424,0.0001198967,0.0007740826,0.9811553],"study_design_scores_gemma":[0.000113951,0.000325059,0.000004753129,0.0005300558,0.0001951936,0.00003231331,0.00004170848,3.7562e-7,0.008610509,0.0001333167,0.9897427,0.0002700811],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009018407,0.9970671,0.00008232175,0.00000351658,0.0004062136,0.0002377391,0.0001078064,0.000009507204,0.00118395],"genre_scores_gemma":[0.001088622,0.9965562,0.00006979705,0.00002578138,0.00006488738,0.00006662161,0.0009883089,0.00003991964,0.001099846],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9889686,"threshold_uncertainty_score":0.9999881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03945930746263283,"score_gpt":0.3102885087988833,"score_spread":0.2708292013362505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}