{"id":"W4308510590","doi":"10.1016/j.immuni.2022.10.014","title":"Innate immune mechanisms of mRNA vaccines","year":2022,"lang":"en","type":"review","venue":"Immunity","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":463,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Szegedi Tudományegyetem; National Institute of Allergy and Infectious Diseases; Vlaamse regering; Universiteit Gent; Knut och Alice Wallenbergs Stiftelse; Bijzonder Onderzoeksfonds UGent; University of California, Los Angeles; Vetenskapsrådet; University of Pennsylvania","keywords":"Innate immune system; Immunogenicity; Biology; Context (archaeology); Adjuvant; Immune system; Immunity; Messenger RNA; Immunology; Virology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007580763,0.001268915,0.001565416,0.001565711,0.0002624312,0.001247143,0.001218079,0.001726975,0.00323803],"category_scores_gemma":[0.0007064557,0.000338592,0.0004284508,0.00143546,0.001022539,0.001397885,0.000781008,0.003019291,0.002471485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001031038,"about_ca_system_score_gemma":0.0009046299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007683742,"about_ca_topic_score_gemma":0.001409448,"domain_scores_codex":[0.9997845,0.00004125944,0.00001911484,0.00003520011,0.00008952364,0.00003045598],"domain_scores_gemma":[0.9997339,0.0001435565,0.00003288181,0.000009748865,0.00005030736,0.00002959943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000149435,0.0001023928,0.00007391461,0.01119307,0.00005751965,0.0001797337,0.00003421865,0.0008318773,0.006230346,0.01331473,0.06738593,0.9004469],"study_design_scores_gemma":[0.00002733384,0.00008133601,0.0002229792,0.001724961,0.00004747279,0.0005557545,0.0000185395,0.0001523111,0.001192855,0.00406587,0.9918944,0.00001603824],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004676712,0.9979187,0.0003346472,0.0003015209,0.0004398979,0.000004224201,0.00001182502,0.000008287387,0.0009341716],"genre_scores_gemma":[0.0004883251,0.9973002,0.000298429,0.0003299703,0.0004895626,0.00001069803,0.00002762549,0.000002316694,0.001052852],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00323803,"threshold_uncertainty_score":0.01083225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03945930746263283,"score_gpt":0.3102885087988833,"score_spread":0.2708292013362505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}