{"id":"W4308512185","doi":"10.2337/db22-0362","title":"N-end Rule–Mediated Proteasomal Degradation of ATGL Promotes Lipid Storage","year":2022,"lang":"en","type":"article","venue":"Diabetes","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Natural Science Foundation of China","keywords":"Adipose triglyceride lipase; Lipolysis; Lipogenesis; Steatosis; Chemistry; Internal medicine; Endocrinology; Cell biology; Adipose tissue; Biochemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001357482,0.0003117794,0.0002386489,0.0001491815,0.0001355941,0.0002728441,0.0001004275,0.0001850524,0.0008828742],"category_scores_gemma":[0.00007610073,0.00008106444,0.0002451665,0.00007727194,0.0001658537,0.0001835294,0.0002073395,0.0003039041,0.000408771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002058107,"about_ca_system_score_gemma":0.0001203186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002099183,"about_ca_topic_score_gemma":0.0004230082,"domain_scores_codex":[0.9999167,0.00001392502,0.00000791237,0.0000249782,0.00001869782,0.00001778877],"domain_scores_gemma":[0.9999132,0.000007831237,0.00003192189,0.00001103857,0.00001282127,0.0000230487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007085979,0.000009244314,0.0002012378,0.00001835321,0.000003318607,0.00004028266,0.00000289654,0.00001982894,0.9988595,0.00004823825,0.00002943154,0.0006967871],"study_design_scores_gemma":[0.00001095095,0.0001165087,0.007229532,0.000004466681,0.000009395476,0.0003368024,0.00001345183,0.0006085598,0.9898012,0.00007101252,0.001793544,0.000004439679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899531,0.003362192,0.004559441,0.0001658783,0.00004097314,0.00001572978,0.0002695746,0.0001176629,0.001515475],"genre_scores_gemma":[0.9953257,0.0007886888,0.001703347,0.00006051353,0.00001427442,0.00001014493,0.0002961009,0.00001636141,0.001785038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008828742,"threshold_uncertainty_score":0.00295347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006868247008856822,"score_gpt":0.2010084436443096,"score_spread":0.1941401966354528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}