{"id":"W4308514768","doi":"10.1016/j.celrep.2022.111624","title":"HIV-1 Vpu restricts Fc-mediated effector functions in vivo","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Uniformed Services University of the Health Sciences; National Institutes of Health; Universität zu Köln; Karolinska Institutet; Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg; Canada Foundation for Innovation; Institute of Infection and Immunity; Deutsche Forschungsgemeinschaft; National Institute on Drug Abuse; Gruber Foundation; Vaccine Research Center; Canadian Institutes of Health Research; Baden-Württemberg Stiftung; University of Maryland; Fonds de Recherche du Québec - Santé; Tulane University; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; International AIDS Vaccine Initiative","keywords":"Antibody-dependent cell-mediated cytotoxicity; Virology; Effector; Biology; Tetherin; Antibody; Epitope; Virus; Glycoprotein; In vivo; Cell biology; Viral envelope; Immunology; Molecular biology; Monoclonal antibody; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002603082,0.000110861,0.0001662655,0.0001824946,0.0002538307,0.000007424175,0.0000741993,0.00007144143,0.00885387],"category_scores_gemma":[0.0001050877,0.0001016221,0.00006457524,0.000300624,0.00005354565,0.00003015756,0.0001302959,0.0003544625,0.006176271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001607833,"about_ca_system_score_gemma":0.000162339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002077916,"about_ca_topic_score_gemma":0.00003830842,"domain_scores_codex":[0.9987549,0.000241503,0.000251999,0.0003108809,0.0000645414,0.0003762235],"domain_scores_gemma":[0.9993496,0.0001623117,0.0000887547,0.0003358493,0.00002139325,0.00004206888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002083151,0.001015566,0.1543501,0.00002000778,0.0000920258,0.007660224,0.0002519732,0.00008920125,0.3615808,0.000002752269,0.4740536,0.0006754335],"study_design_scores_gemma":[0.00111582,0.0004362406,0.01909494,0.000004827665,0.00001708481,0.0005458456,0.0001473224,0.000001545504,0.01434451,0.000007912922,0.9641533,0.0001306017],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732879,0.001789861,0.000006711718,0.0001389887,0.0008740497,0.0004155041,0.0004353364,0.00007550957,0.02297616],"genre_scores_gemma":[0.9487284,0.00002132367,0.000006145833,0.00003626964,0.0000143253,0.0002678824,0.002592355,0.00001278907,0.04832055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4900998,"threshold_uncertainty_score":0.9945976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009697066961919864,"score_gpt":0.2266574260840502,"score_spread":0.2169603591221304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}