{"id":"W4308514768","doi":"10.1016/j.celrep.2022.111624","title":"HIV-1 Vpu restricts Fc-mediated effector functions in vivo","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Uniformed Services University of the Health Sciences; National Institutes of Health; Universität zu Köln; Karolinska Institutet; Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg; Canada Foundation for Innovation; Institute of Infection and Immunity; Deutsche Forschungsgemeinschaft; National Institute on Drug Abuse; Gruber Foundation; Vaccine Research Center; Canadian Institutes of Health Research; Baden-Württemberg Stiftung; University of Maryland; Fonds de Recherche du Québec - Santé; Tulane University; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; International AIDS Vaccine Initiative","keywords":"Antibody-dependent cell-mediated cytotoxicity; Virology; Effector; Biology; Tetherin; Antibody; Epitope; Virus; Glycoprotein; In vivo; Cell biology; Viral envelope; Immunology; Molecular biology; Monoclonal antibody; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002006348,0.0003071759,0.0002751786,0.0002043691,0.0001074061,0.0004060314,0.0002396862,0.0002615005,0.001457756],"category_scores_gemma":[0.0001755752,0.0001355399,0.00009558695,0.00007519707,0.0002582444,0.000208778,0.0001506481,0.0009244265,0.000324623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002187819,"about_ca_system_score_gemma":0.0002009848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004499736,"about_ca_topic_score_gemma":0.0004865329,"domain_scores_codex":[0.9998108,0.00004125541,0.000008602297,0.00003428684,0.00003547265,0.00006958853],"domain_scores_gemma":[0.9998549,0.00005853537,0.00001936849,0.00002833316,0.00001097782,0.00002796744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002671256,0.0001738363,0.0002021187,0.0000324558,0.000003906129,0.0000333117,0.00001950849,0.00009802532,0.9948967,0.0003141675,0.0001173509,0.003841565],"study_design_scores_gemma":[0.00004044078,0.001536875,0.002446768,0.00001238308,0.00001058224,0.0003840908,0.0000208295,0.001242667,0.9914322,0.0002022112,0.002668021,0.000002921262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922642,0.002137826,0.001942335,0.0001369177,0.0000388448,0.00002323758,0.0001033808,0.00009974233,0.003253718],"genre_scores_gemma":[0.9968311,0.0006588147,0.0005707319,0.00003988911,0.00001900715,0.00001444177,0.0001335376,0.00001268044,0.0017197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001457756,"threshold_uncertainty_score":0.004876673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009697066961919864,"score_gpt":0.2266574260840502,"score_spread":0.2169603591221304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}