{"id":"W4308515918","doi":"10.1007/s12192-022-01307-8","title":"Role of unfolded protein response and ER-associated degradation under freezing, anoxia, and dehydration stresses in the freeze-tolerant wood frogs","year":2022,"lang":"en","type":"article","venue":"Cell Stress and Chaperones","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Unfolded protein response; Endoplasmic-reticulum-associated protein degradation; ATF4; ATF6; Downregulation and upregulation; Cell biology; Endoplasmic reticulum; Protein degradation; Biology; Protein folding; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001112537,0.0001891937,0.0002072018,0.0004072084,0.0003358118,0.0002419208,0.0001063586,0.0002687384,0.0008102684],"category_scores_gemma":[0.00006848468,0.0001179911,0.0003110357,0.0001474049,0.0002504364,0.0002646917,0.0001704577,0.0002786982,0.0001573882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001621382,"about_ca_system_score_gemma":0.0001053823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007250195,"about_ca_topic_score_gemma":0.001001861,"domain_scores_codex":[0.9999399,0.000008645833,0.000005179025,0.00002051335,0.00000946866,0.00001640071],"domain_scores_gemma":[0.9999347,0.000003554205,0.00002537852,0.000004083202,0.00001099272,0.00002128139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002237507,0.00002861445,0.006105662,0.00006188088,0.00001590236,0.0001628656,0.000100969,0.0000547356,0.9917731,0.00007057488,0.00002648313,0.001375325],"study_design_scores_gemma":[0.00002213375,0.0008664241,0.8262705,0.00002931791,0.00006158329,0.001532555,0.0007039817,0.0005951746,0.1671099,0.0002121365,0.002575412,0.00002088117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979544,0.0008492627,0.0003824382,0.00003040623,0.000006481755,0.000008982805,0.0001752278,0.00001307993,0.0005796698],"genre_scores_gemma":[0.9967713,0.0006191551,0.0007295103,0.00004798632,0.00000870767,0.00002078959,0.0003546528,0.000005294152,0.001442622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008102684,"threshold_uncertainty_score":0.002710581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005258352434095896,"score_gpt":0.1991000553481335,"score_spread":0.1938417029140377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}