{"id":"W4308515918","doi":"10.1007/s12192-022-01307-8","title":"Role of unfolded protein response and ER-associated degradation under freezing, anoxia, and dehydration stresses in the freeze-tolerant wood frogs","year":2022,"lang":"en","type":"article","venue":"Cell Stress and Chaperones","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Unfolded protein response; Endoplasmic-reticulum-associated protein degradation; ATF4; ATF6; Downregulation and upregulation; Cell biology; Endoplasmic reticulum; Protein degradation; Biology; Protein folding; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001577058,0.0001282083,0.0001305485,0.00004131757,0.0001743376,0.00003625184,0.00008905803,0.00006117296,0.0000132457],"category_scores_gemma":[0.00003238132,0.000103953,0.00002404009,0.0000578277,0.00009411165,0.00001164075,0.0001145168,0.00007919801,6.14392e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007127259,"about_ca_system_score_gemma":0.0000331964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003218453,"about_ca_topic_score_gemma":0.000580025,"domain_scores_codex":[0.9990611,0.0002179983,0.0001764957,0.0002548493,0.0001450376,0.0001444838],"domain_scores_gemma":[0.9996311,0.00004023684,0.0001073179,0.000150659,0.00002400156,0.0000466597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006067862,0.0003649295,0.02579741,0.00008403624,0.0000293449,0.000005791903,0.001061869,0.0002203677,0.9696858,0.0002527913,0.00003461647,0.001856291],"study_design_scores_gemma":[0.004663868,0.001494393,0.2450483,0.0001406947,0.0001101028,0.00001377931,0.02142584,0.002370397,0.7219276,0.001295998,0.0009114688,0.000597471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936271,0.005683718,0.0000122481,0.0001705873,0.0000151365,0.0002674715,0.0001424626,0.000004812514,0.00007643735],"genre_scores_gemma":[0.9991391,0.0004146641,0.00002330237,0.00006029041,0.00001523503,0.00008755825,0.0001721142,0.00001059536,0.00007716307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2477581,"threshold_uncertainty_score":0.423908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005258352434095896,"score_gpt":0.1991000553481335,"score_spread":0.1938417029140377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}