{"id":"W4308520829","doi":"10.1101/2022.10.26.22281550","title":"Functional and molecular characterization of suicidality factors using phenotypic and genome-wide data","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Suicide and Self-Harm Studies","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto","funders":"Medical Research Council; National Institutes of Health; One Mind","keywords":"Genome-wide association study; Heritability; Quantitative trait locus; Genetic association; Genetics; SNP; Trait; Biology; Population; Gene; Single-nucleotide polymorphism; Genotype; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001892011,0.0004180697,0.0003742567,0.001020554,0.0001859585,0.0005801838,0.0003153413,0.0003375275,0.001890737],"category_scores_gemma":[0.004234363,0.0001645365,0.0009836584,0.001348102,0.0002957343,0.0002907507,0.0004958336,0.0004714569,0.0001585831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001196884,"about_ca_system_score_gemma":0.0001795627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001725586,"about_ca_topic_score_gemma":0.001390612,"domain_scores_codex":[0.999138,0.0004668762,0.00007921564,0.0001986545,0.00007189016,0.00004529712],"domain_scores_gemma":[0.9969738,0.001390096,0.0008854857,0.000398743,0.0002141552,0.0001377173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003596398,0.00004018994,0.9790688,0.00005282203,0.0007574655,0.0001474321,0.00009728159,0.001473157,0.01243009,0.0001782861,0.000106804,0.005287893],"study_design_scores_gemma":[0.00001957177,0.0001462669,0.9935412,0.000009293791,0.0002253761,0.0002403754,0.00007795775,0.004115932,0.001105483,0.0003832559,0.0001257675,0.000009480737],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963188,0.0001295161,0.00256004,0.00004560209,0.000003370672,0.000008197107,0.0007527744,0.00002466993,0.0001570465],"genre_scores_gemma":[0.9981062,0.0000316505,0.001202009,0.00001343428,0.000003319065,0.000008952081,0.0005810754,0.000004652737,0.00004866914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001892011,"threshold_uncertainty_score":0.01000607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1066225609429228,"score_gpt":0.3257290567105095,"score_spread":0.2191064957675867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}