{"id":"W4308522406","doi":"10.1186/s40164-022-00339-1","title":"Pan-cancer landscape of aberrant DNA Methylation across childhood Cancers: Molecular Characteristics and Clinical relevance","year":2022,"lang":"en","type":"letter","venue":"Experimental Hematology and Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Genome British Columbia; University of British Columbia","funders":"Southern Methodist University","keywords":"dNaM; DNA methylation; Cancer; Epigenetics; Medicine; Carcinogenesis; Methylation; CpG site; Oncology; Cancer research; Internal medicine; Bioinformatics; Biology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003552414,0.0002015031,0.0003439816,0.0008702551,0.0002903593,0.000408131,0.0001776665,0.0001934954,0.001203566],"category_scores_gemma":[0.0007572208,0.0001458362,0.0001977097,0.001166453,0.0002517022,0.0002171221,0.0004296063,0.0003110574,0.0001305977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003199592,"about_ca_system_score_gemma":0.0003019313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003235468,"about_ca_topic_score_gemma":0.006676299,"domain_scores_codex":[0.9997234,0.00003639355,0.00002404485,0.0001088255,0.00004596032,0.00006135267],"domain_scores_gemma":[0.9995009,0.0001152933,0.0001952936,0.00005176408,0.00006634847,0.00007038954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002595534,0.000009669769,0.950259,0.00007824611,0.0000938154,0.0002345733,0.0001425992,0.0001813095,0.03129463,0.0001071124,0.0002009338,0.01713856],"study_design_scores_gemma":[0.000004063565,0.0000589985,0.9915752,0.000007333968,0.00007558736,0.001770178,0.0001597307,0.0003448583,0.004583374,0.00009395603,0.001322958,0.000003806896],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937732,0.002398719,0.001570275,0.00006149205,0.000004589969,0.00001579277,0.001310896,0.00004447875,0.0008205879],"genre_scores_gemma":[0.9970266,0.0006229235,0.001179774,0.00002323812,0.000005816266,0.000009864482,0.0009466251,0.0000119146,0.0001731615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003235468,"threshold_uncertainty_score":0.006433249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01870720497526948,"score_gpt":0.3588769491785945,"score_spread":0.340169744203325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}