{"id":"W4308522406","doi":"10.1186/s40164-022-00339-1","title":"Pan-cancer landscape of aberrant DNA Methylation across childhood Cancers: Molecular Characteristics and Clinical relevance","year":2022,"lang":"en","type":"letter","venue":"Experimental Hematology and Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Genome British Columbia; University of British Columbia","funders":"Southern Methodist University","keywords":"dNaM; DNA methylation; Cancer; Epigenetics; Medicine; Carcinogenesis; Methylation; CpG site; Oncology; Cancer research; Internal medicine; Bioinformatics; Biology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003543634,0.0003293417,0.0008123614,0.00005656813,0.0001519934,0.00001198302,0.0001762324,0.001264138,0.0001181022],"category_scores_gemma":[0.00008415064,0.0003377855,0.0001395794,0.0000647889,0.000453895,0.000005886363,0.0003504097,0.0007213687,0.000001388462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005852074,"about_ca_system_score_gemma":0.0002038262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004227457,"about_ca_topic_score_gemma":0.00003097445,"domain_scores_codex":[0.9975767,0.0004362781,0.0007192846,0.0007421351,0.000154038,0.0003716346],"domain_scores_gemma":[0.9987842,0.0001566081,0.0005958932,0.0003287264,0.00006343749,0.00007111652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003313024,0.002052539,0.07708767,0.00118562,0.003664338,0.0009439716,0.004814421,0.00002683415,0.667588,0.0009579166,0.1215784,0.1167872],"study_design_scores_gemma":[0.002618044,0.00352369,0.008445002,0.00005828912,0.0001839932,0.0001380372,0.0004394272,0.00004241239,0.3897934,0.0002011387,0.5938305,0.0007261361],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9226729,0.066564,0.0000930751,0.008790179,0.0009724434,0.0003926007,0.0002227866,0.00001156869,0.0002804376],"genre_scores_gemma":[0.9564047,0.01432703,0.0005108314,0.0262053,0.0009035209,0.0001981341,0.001189131,0.00007055461,0.0001908429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.472252,"threshold_uncertainty_score":0.9999074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01870720497526948,"score_gpt":0.3588769491785945,"score_spread":0.340169744203325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}