{"id":"W4308531328","doi":"10.1002/anie.202214729","title":"Single Atom Ring Contraction of Peptide Macrocycles Using Cornforth Rearrangement","year":2022,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Linker; Peptide; Chemistry; Ring (chemistry); Ring size; Contraction (grammar); Substrate (aquarium); Kinetics; Combinatorial chemistry; Cyclic peptide; Stereochemistry; Computer science; Biochemistry; Organic chemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00033223,0.0004495322,0.0002675675,0.0002225511,0.0001779569,0.0002651613,0.0003338276,0.0003623482,0.001514473],"category_scores_gemma":[0.0005194294,0.0001532103,0.0002673449,0.0001898149,0.0003868562,0.0005384804,0.0005078301,0.0007330687,0.0004043948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001889093,"about_ca_system_score_gemma":0.0002949824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002453159,"about_ca_topic_score_gemma":0.0006821579,"domain_scores_codex":[0.9997947,0.00003872428,0.00001477556,0.00006150029,0.00003582326,0.00005452813],"domain_scores_gemma":[0.9997393,0.00008877637,0.00007964202,0.00004896786,0.0000175663,0.00002571015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001419407,0.00005104674,0.0001469418,0.0001133562,0.00001790657,0.0003285784,0.00009530158,0.00111539,0.9841874,0.003027979,0.000155848,0.01061825],"study_design_scores_gemma":[0.0000218019,0.000695924,0.0004321591,0.000007732551,0.000009709287,0.0002503972,0.00001656909,0.0006839769,0.992683,0.000220749,0.004961696,0.00001641479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9592417,0.002245239,0.02798127,0.0002307126,0.0001162242,0.0002162958,0.0002336344,0.0002543817,0.009480683],"genre_scores_gemma":[0.9804611,0.001470891,0.01501549,0.000108559,0.00002238066,0.00009219049,0.0001715212,0.00006265382,0.002595377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001514473,"threshold_uncertainty_score":0.005066395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01706430450647285,"score_gpt":0.254699329049059,"score_spread":0.2376350245425861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}