{"id":"W4308531328","doi":"10.1002/anie.202214729","title":"Single Atom Ring Contraction of Peptide Macrocycles Using Cornforth Rearrangement","year":2022,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Linker; Peptide; Chemistry; Ring (chemistry); Ring size; Contraction (grammar); Substrate (aquarium); Kinetics; Combinatorial chemistry; Cyclic peptide; Stereochemistry; Computer science; Biochemistry; Organic chemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001100424,0.00007940619,0.00009522185,0.00004387836,0.00008062187,0.00001349651,0.0001171175,0.00003600093,0.0004495856],"category_scores_gemma":[0.00003550482,0.00008707951,0.0001179956,0.00005852996,0.00002961786,0.000009567576,0.000101577,0.00006197014,0.000001108898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009274761,"about_ca_system_score_gemma":0.00001638471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007433593,"about_ca_topic_score_gemma":0.00001285324,"domain_scores_codex":[0.9992417,0.00001399328,0.0002014409,0.0001846553,0.0002616797,0.00009658611],"domain_scores_gemma":[0.9995956,0.00001299654,0.0001684614,0.0001021193,0.00009080747,0.00003005386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006808484,0.0001099095,0.0009380671,0.000006556867,0.00009716643,0.000001332771,0.00001731007,0.0002897065,0.9962034,0.00002806337,0.00136111,0.0008793101],"study_design_scores_gemma":[0.0002646701,0.00003576227,0.0003364038,0.00001156803,0.00003208378,0.00001116752,0.0001428964,0.0002152707,0.9447131,0.00006693848,0.05408053,0.00008964487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926979,0.0001113514,0.003656015,0.0001491894,0.000283008,0.00005430245,0.0001232388,0.000008440174,0.002916553],"genre_scores_gemma":[0.9979213,0.00004529139,0.0003361481,0.00009457867,0.000554412,0.00001852408,0.0007905458,0.00001054629,0.0002286742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05271943,"threshold_uncertainty_score":0.4922647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01706430450647285,"score_gpt":0.254699329049059,"score_spread":0.2376350245425861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}