{"id":"W4308531530","doi":"10.1002/ange.202214729","title":"Single Atom Ring Contraction of Peptide Macrocycles Using Cornforth Rearrangement","year":2022,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Linker; Peptide; Ring (chemistry); Ring size; Cyclic peptide; Substrate (aquarium); Kinetics; Contraction (grammar); Combinatorial chemistry; Stereochemistry; Organic chemistry; Computer science; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003124308,0.000394172,0.0002203411,0.0002498821,0.0001605343,0.0002617358,0.0003236789,0.0003273127,0.001692345],"category_scores_gemma":[0.0004400485,0.0001429117,0.0002137726,0.0001731527,0.000344576,0.0004010933,0.0004080282,0.0005716485,0.0003810741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002125093,"about_ca_system_score_gemma":0.0002710083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002968266,"about_ca_topic_score_gemma":0.0007159911,"domain_scores_codex":[0.9998055,0.00003896171,0.00001265309,0.00005186427,0.00003591615,0.00005512515],"domain_scores_gemma":[0.9997308,0.00008323028,0.00008544725,0.0000493951,0.00001954981,0.00003157448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000117166,0.00004465776,0.0001224223,0.00006668274,0.00001335364,0.0002230813,0.00005714435,0.0009201819,0.9903216,0.002179892,0.0001293416,0.00580453],"study_design_scores_gemma":[0.00002203097,0.000573114,0.0004313653,0.000005596258,0.000006463826,0.0001404401,0.00001178401,0.0008134987,0.9943836,0.0001367433,0.003462327,0.00001294366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756251,0.001223433,0.01497011,0.0001526445,0.00007853299,0.0001379245,0.0001924333,0.0002008339,0.007419159],"genre_scores_gemma":[0.9897448,0.0006433976,0.0074616,0.00006451481,0.00001255938,0.00005763623,0.0001065397,0.00003848826,0.001870399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001692345,"threshold_uncertainty_score":0.005661488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01972828258990405,"score_gpt":0.2437418293636613,"score_spread":0.2240135467737573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}