{"id":"W4308532025","doi":"10.1002/chem.202203311","title":"A Triazolium‐Anchored Self‐Immolative Linker Enables Self‐Assembly‐Driven siRNA Binding and Esterase‐Induced Release","year":2022,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"HORIZON EUROPE European Research Council; Ministère de l'Enseignement Supérieur, de la Recherche, de la Science et de la Technologie; Ministère de l'Europe et des Affaires Étrangères; Agence Nationale de la Recherche; Deutscher Akademischer Austauschdienst; European Commission; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation","keywords":"Linker; Amphiphile; Moiety; Chemistry; Esterase; Combinatorial chemistry; Nucleic acid; Prodrug; Nanocarriers; Biophysics; Enzyme; Stereochemistry; Biochemistry; Organic chemistry; Drug delivery; Copolymer; Polymer; Biology; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002014161,0.0003489892,0.00014396,0.000227516,0.000145057,0.0002957244,0.0003934985,0.0004240007,0.00074964],"category_scores_gemma":[0.000285098,0.0001894515,0.0002516185,0.0001467051,0.000267374,0.0002915913,0.0002729219,0.0005812689,0.00039793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004629873,"about_ca_system_score_gemma":0.0003977387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005320459,"about_ca_topic_score_gemma":0.0009419588,"domain_scores_codex":[0.999877,0.00001543802,0.00001278419,0.00002266446,0.00003968911,0.00003243965],"domain_scores_gemma":[0.9998714,0.00002185312,0.00005769893,0.00001223234,0.00001434518,0.00002249722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001542899,0.00001486976,0.00002993621,0.00002365396,0.000002260955,0.00006062352,0.0000203556,0.0001311014,0.9981452,0.0003136452,0.00003701073,0.00120579],"study_design_scores_gemma":[0.000005411697,0.00008562844,0.0001466658,0.000002157421,0.00000445833,0.00009699041,0.000003083675,0.0008062284,0.997763,0.00001404285,0.001068185,0.00000418235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9592553,0.001889148,0.03317969,0.0003144251,0.00006157016,0.0000865972,0.0001334756,0.0006304592,0.004449316],"genre_scores_gemma":[0.9842883,0.0007092439,0.01087555,0.00007863093,0.00001194571,0.00005630212,0.0001313025,0.00002876103,0.003819931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00074964,"threshold_uncertainty_score":0.003359258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01377856683731346,"score_gpt":0.2257738155064939,"score_spread":0.2119952486691804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}