{"id":"W4308562598","doi":"10.1101/2022.11.08.515436","title":"Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Barts and The London School of Medicine and Dentistry; Medical Research Council; National Institutes of Health; Samsung Biomedical Research Institute; Chinese Academy of Medical Sciences; UK Coronavirus Immunology Consortium; University College London Hospitals NHS Foundation Trust; Rosetrees Trust; Institute for Translational Medicine and Therapeutics; British Heart Foundation; University College London; Cystic Fibrosis Trust; Cancer Research UK; GW Pharmaceuticals; Barts Charity; UK Research and Innovation; NIHR Oxford Biomedical Research Centre; John Black Charitable Foundation; Wellcome Trust; National Institute for Health and Care Research","keywords":"Lymphocytic choriomeningitis; T-cell receptor; Biology; Virology; Repertoire; Epitope; T cell; Immunity; Immunology; Cd4 t cell; Viral infection; Virus; Immune system; CD8; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001976484,0.0001876941,0.0001565647,0.000231393,0.0001626035,0.0003053859,0.0001368467,0.0002155499,0.005361508],"category_scores_gemma":[0.0002781718,0.00009711301,0.0001722024,0.00009183324,0.0001200916,0.0001454533,0.0002541518,0.0005909984,0.00171852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001489847,"about_ca_system_score_gemma":0.00008920673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001443053,"about_ca_topic_score_gemma":0.0002657725,"domain_scores_codex":[0.9998696,0.00001800765,0.000008746766,0.0000302101,0.00003731617,0.0000361275],"domain_scores_gemma":[0.9997727,0.0000934425,0.00001574839,0.00003339605,0.0000255853,0.00005910015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000185043,0.00003991639,0.0005866639,0.00002003149,0.000003173942,0.0000823428,0.00002919521,0.00005027354,0.9964032,0.000117761,0.0002527911,0.002229601],"study_design_scores_gemma":[0.0001314602,0.001157126,0.04203165,0.00001598873,0.00003592564,0.00153073,0.0001189961,0.001929772,0.9397637,0.000461091,0.01281144,0.00001215309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906265,0.000661001,0.003616749,0.0001652256,0.00008845027,0.00005292336,0.0006460052,0.0001671654,0.003976057],"genre_scores_gemma":[0.9749111,0.0004599783,0.004585498,0.0002199927,0.0001453306,0.00009504862,0.002857556,0.0001362132,0.01658929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005361508,"threshold_uncertainty_score":0.01793599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03425180672436727,"score_gpt":0.3066482795805525,"score_spread":0.2723964728561852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}