{"id":"W4308564938","doi":"10.1101/2022.11.08.515634","title":"Clinical PARP inhibitors allosterically induce PARP2 retention on DNA","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Allosteric regulation; PARP1; DNA damage; Poly ADP ribose polymerase; DNA; Chemistry; DNA repair; Cell biology; Biology; Cancer research; Biochemistry; Enzyme; Polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002085593,0.0002812607,0.0002450155,0.0001400479,0.0001579407,0.0003593712,0.0002917592,0.0003182258,0.007781011],"category_scores_gemma":[0.0002600292,0.0001581084,0.0001935969,0.0001720286,0.000260272,0.0002025844,0.0001470882,0.0007364731,0.001284772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002720841,"about_ca_system_score_gemma":0.0001411349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002786538,"about_ca_topic_score_gemma":0.0002626927,"domain_scores_codex":[0.9997918,0.00003331979,0.00001320428,0.00005645166,0.00006505004,0.00004012822],"domain_scores_gemma":[0.999881,0.00002615579,0.00003592311,0.00002641559,0.00001357441,0.0000169263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005365346,0.00009646187,0.0002850294,0.00007420836,0.00001741899,0.00005318465,0.00001946155,0.0002254981,0.9925368,0.0004697987,0.0008473463,0.004838206],"study_design_scores_gemma":[0.00005532877,0.0003609112,0.001930438,0.000003241727,0.000008611305,0.0002287061,0.000009343571,0.0007291302,0.9922199,0.00008563989,0.004364431,0.000004273334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699719,0.004517223,0.01055553,0.0006766688,0.0002347942,0.00007526756,0.001634517,0.0005781737,0.01175598],"genre_scores_gemma":[0.989256,0.000600516,0.002479204,0.0002010879,0.00002828433,0.00002861026,0.0008898282,0.00005099849,0.006465537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007781011,"threshold_uncertainty_score":0.02603006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04991117370171597,"score_gpt":0.3125301449260652,"score_spread":0.2626189712243492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}