{"id":"W4308566761","doi":"10.1038/s41467-022-34477-1","title":"Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Rosetrees Trust; European Commission; Medical Research Council; Diabetes UK","keywords":"Autoimmunity; Blockade; Immunology; Medicine; T cell; Cell biology; Biology; Computational biology; Cancer research; Immune system; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002063011,0.0008428351,0.0005762912,0.0003442068,0.0001670368,0.0006159653,0.0003568298,0.00051984,0.0008885827],"category_scores_gemma":[0.0001150933,0.0001706977,0.0003479254,0.0002046788,0.0003461467,0.0003294698,0.0002409903,0.001349923,0.000324199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000341154,"about_ca_system_score_gemma":0.0004036033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003296878,"about_ca_topic_score_gemma":0.0008212759,"domain_scores_codex":[0.9996393,0.00006313176,0.00003227762,0.00006264901,0.00007817083,0.000124444],"domain_scores_gemma":[0.9998868,0.00001803277,0.00003008696,0.00001979155,0.00000728019,0.00003808397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000154084,0.0001198504,0.00008681373,0.00003017735,0.000007146549,0.00002859517,0.000006672175,0.0001328612,0.9980277,0.00007326173,0.00004424001,0.001288466],"study_design_scores_gemma":[0.00007353254,0.001522531,0.001022917,0.00000522731,0.00003401895,0.0002725341,0.000008321612,0.0006385021,0.9944401,0.00003589429,0.001941032,0.000005464935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931602,0.001674479,0.002951807,0.0001822066,0.0001137124,0.00005129829,0.0001501344,0.0001453461,0.001570833],"genre_scores_gemma":[0.9930509,0.0007272683,0.003934875,0.0001070401,0.00007913154,0.0000790733,0.0002346422,0.00003007221,0.001757015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008885827,"threshold_uncertainty_score":0.002972603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01735742358857176,"score_gpt":0.2417157830424983,"score_spread":0.2243583594539266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}