{"id":"W4308574760","doi":"10.1073/pnas.2216239119","title":"Porphyrin nanoemulsion for antimicrobial photodynamic therapy: effective delivery to inactivate biofilm-related infections","year":2022,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Biofilm; Staphylococcus aureus; Antimicrobial; Microbiology; Photodynamic therapy; Photosensitizer; In vivo; Porphyrin; Chemistry; Bacteria; Biology; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001368192,0.0001231678,0.0002491891,0.0004685684,0.0007096446,0.00001157307,0.0004355933,0.00005075944,0.00002893532],"category_scores_gemma":[0.0004652925,0.00008600918,0.000159733,0.001582046,0.0004982041,0.000188055,0.000303705,0.0002853757,8.155715e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002615278,"about_ca_system_score_gemma":0.00007768872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003229801,"about_ca_topic_score_gemma":1.522989e-7,"domain_scores_codex":[0.9981917,0.0000193484,0.0002904327,0.0003075907,0.0009608598,0.0002301347],"domain_scores_gemma":[0.999019,0.0002589668,0.0002741349,0.00001234019,0.0003871316,0.00004838108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004392192,0.000225072,0.001246763,0.00004719277,0.00009869336,1.287718e-8,0.0003438415,0.0001894165,0.9946598,0.001061959,0.0007363004,0.000951698],"study_design_scores_gemma":[0.001282449,0.001143117,0.05717237,0.0000932679,0.00002059437,0.00002839986,0.0002919874,0.001023973,0.9339979,0.004171996,0.0006611553,0.0001127376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933485,0.00007837347,9.273666e-7,0.003765858,0.00004621172,0.001828824,0.00009880283,0.00002496288,0.0008074917],"genre_scores_gemma":[0.9985976,0.00006774582,0.0002558268,0.0005246349,0.00003097446,0.000300163,9.444273e-7,0.000009788905,0.0002123268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06066188,"threshold_uncertainty_score":0.5458084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02423451681758427,"score_gpt":0.3276487589552214,"score_spread":0.3034142421376371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}