{"id":"W4308579440","doi":"10.3390/cells11223530","title":"AV-101, a Pro-Drug Antagonist at the NMDA Receptor Glycine Site, Reduces L-Dopa Induced Dyskinesias in MPTP Monkeys","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Vistagen Therapeutics","keywords":"MPTP; Pharmacology; Amantadine; NMDA receptor; Antagonist; Memantine; Agonist; Medicine; Receptor antagonist; Adverse effect; Parkinson's disease; Chemistry; Receptor; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006015091,0.0002623942,0.0002677046,0.0002539062,0.001341801,0.0001105891,0.001298625,0.00003417094,0.001562932],"category_scores_gemma":[0.0002578512,0.0002013287,0.00008935735,0.001887436,0.0004987701,0.0002260575,0.001228546,0.001008792,0.0006613814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001695616,"about_ca_system_score_gemma":0.0001866589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005872525,"about_ca_topic_score_gemma":0.00002344173,"domain_scores_codex":[0.9957535,0.001115653,0.0003811278,0.001073991,0.0008461372,0.0008296325],"domain_scores_gemma":[0.9984642,0.0006359124,0.0001543013,0.0005464629,0.00003246773,0.000166715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002420453,0.0002763943,0.0008521311,0.00001137932,0.000001192556,0.000307951,0.0005122154,0.00009408691,0.979463,0.00001067872,0.01794639,0.0002825804],"study_design_scores_gemma":[0.0007601535,0.0002503592,0.0003560843,0.00000513353,0.000004120768,0.00006269541,0.0001279218,0.0002196299,0.9703223,0.00001419933,0.02766696,0.0002104414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914837,0.0000366359,1.916924e-7,0.004519805,0.001528495,0.001015499,0.000062498,0.00008025514,0.001272913],"genre_scores_gemma":[0.9741967,0.0001643474,0.000003905853,0.003299367,0.0001223475,0.0002998493,0.000003123497,0.00004152484,0.02186885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02059594,"threshold_uncertainty_score":0.9999583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0527398471786158,"score_gpt":0.3204061271375821,"score_spread":0.2676662799589663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}