{"id":"W4308579967","doi":"10.1038/s41370-022-00494-x","title":"Developing an internal threshold of toxicological concern (iTTC)","year":2022,"lang":"en","type":"article","venue":"Journal of Exposure Science & Environmental Epidemiology","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"ARC Resources (Canada); The Scarborough Hospital; Arup Group (Canada); University of Toronto","funders":"American Chemistry Council","keywords":"Percentile; Toxicokinetics; Inhalation exposure; Internal dose; Chemical safety; Toxicology; Chemistry; Mathematics; Statistics; Toxicity; Biology; Organic chemistry; Radiochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01154211,0.001598816,0.001318801,0.006885643,0.001030301,0.004363455,0.002646846,0.00163172,0.003081408],"category_scores_gemma":[0.02912569,0.000705725,0.003877453,0.003639863,0.001321513,0.003126453,0.003441337,0.002688276,0.001869349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004217364,"about_ca_system_score_gemma":0.007688939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00907167,"about_ca_topic_score_gemma":0.008091797,"domain_scores_codex":[0.990196,0.001776541,0.0007280626,0.001887548,0.004952335,0.0004594538],"domain_scores_gemma":[0.9732299,0.008866929,0.003545265,0.002626481,0.01123877,0.0004926632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003712624,0.0004673286,0.07755367,0.003357029,0.001356767,0.000746339,0.0006367274,0.44917,0.03224454,0.06470627,0.03551748,0.3338725],"study_design_scores_gemma":[0.00008658597,0.0006893246,0.018532,0.0007168812,0.0007493788,0.0009355406,0.0004530662,0.7733766,0.0501368,0.08115261,0.07292467,0.0002465269],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.0290306,0.001195921,0.9448441,0.0007602895,0.0001577049,0.0007543624,0.005876051,0.002239455,0.01514158],"genre_scores_gemma":[0.3127078,0.001471676,0.6652133,0.001040611,0.000155846,0.001561283,0.01393683,0.0008620628,0.003050704],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.01154211,"threshold_uncertainty_score":0.06104124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05330007812663158,"score_gpt":0.3894590375345839,"score_spread":0.3361589594079524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}