{"id":"W4308620242","doi":"10.1002/ange.202211940","title":"Synthetic Zwitterionic <i>Streptococcus pneumoniae</i> Type 1 Oligosaccharides Carrying Labile <i>O</i>‐Acetyl Esters","year":2022,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"H2020 European Research Council; Agencia Estatal de Investigación; Aard- en Levenswetenschappen, Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Chemistry; Trisaccharide; Glycosidic bond; Polysaccharide; Hydrolysis; Oligosaccharide; Stereochemistry; Nuclear magnetic resonance spectroscopy; Galactose; Carbohydrate conformation; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001303049,0.0005792119,0.000143674,0.0001386302,0.00009652581,0.0001805768,0.0001648305,0.0002040683,0.0007348883],"category_scores_gemma":[0.0001550294,0.0001427911,0.0001615079,0.000170201,0.0001083287,0.0002109939,0.0002034819,0.0002710375,0.0005307224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001416425,"about_ca_system_score_gemma":0.0002497949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003495919,"about_ca_topic_score_gemma":0.0008110076,"domain_scores_codex":[0.9999043,0.00002185847,0.000009461246,0.00001235333,0.00001868422,0.0000334166],"domain_scores_gemma":[0.999928,0.000007191959,0.00002736003,0.000006938538,0.00001304105,0.00001740744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004162018,0.000009318176,0.0000743512,0.00007391498,0.000004707222,0.00007369628,0.00002054885,0.0001782649,0.9967269,0.0002428565,0.00005513847,0.002498676],"study_design_scores_gemma":[0.000006679294,0.0002525117,0.0004856552,0.000006382648,0.000009460618,0.0001106439,0.00001627451,0.0002389359,0.9953189,0.00004354969,0.003503189,0.000007753306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812293,0.001499898,0.01051109,0.00009200563,0.00006395522,0.0001225878,0.0004778889,0.00009694073,0.005906219],"genre_scores_gemma":[0.9804361,0.002309482,0.01403982,0.00006781993,0.00002139786,0.00006835166,0.0004054544,0.00003324659,0.002618385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007348883,"threshold_uncertainty_score":0.002458453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01951197389396454,"score_gpt":0.2612735349838394,"score_spread":0.2417615610898748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}