{"id":"W4308638869","doi":"10.1002/anie.202211940","title":"Synthetic Zwitterionic <i>Streptococcus pneumoniae</i> Type 1 Oligosaccharides Carrying Labile <i>O</i>‐Acetyl Esters","year":2022,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"China Scholarship Council; Instituto de Salud Carlos III; H2020 European Research Council; Agencia Estatal de Investigación; Aard- en Levenswetenschappen, Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Chemistry; Trisaccharide; Glycosidic bond; Polysaccharide; Hydrolysis; Oligosaccharide; Stereochemistry; Nuclear magnetic resonance spectroscopy; Galactose; Carbohydrate conformation; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001125512,0.0006031038,0.0001666692,0.0001278093,0.00009855603,0.0001776188,0.000174746,0.0002060991,0.0007370805],"category_scores_gemma":[0.0001420024,0.0001436734,0.000164427,0.0001776579,0.0001033442,0.0002235683,0.0002081743,0.0003036669,0.0005451147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000143937,"about_ca_system_score_gemma":0.0002664553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003471414,"about_ca_topic_score_gemma":0.0008165549,"domain_scores_codex":[0.999909,0.00001720273,0.00000850126,0.00001238829,0.00001955359,0.00003336739],"domain_scores_gemma":[0.9999372,0.000006156313,0.00002412014,0.000005496932,0.00001145304,0.00001569168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004217904,0.0000100734,0.00008132425,0.00008935214,0.000005202774,0.00008580268,0.00002317133,0.0001864185,0.995736,0.0002942824,0.00006454559,0.003381684],"study_design_scores_gemma":[0.000006983207,0.0002859997,0.0005245371,0.000007419009,0.00001191028,0.0001392534,0.0000181062,0.0002277628,0.9940245,0.00005656411,0.004688279,0.000008652105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760267,0.002333489,0.01358425,0.0001130394,0.00008239812,0.0001574277,0.0005679745,0.0001146876,0.007020087],"genre_scores_gemma":[0.9715254,0.00402279,0.02029143,0.00008898754,0.00002714122,0.00009638305,0.0005602614,0.00004032653,0.003347352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007370805,"threshold_uncertainty_score":0.002465725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01683029971092561,"score_gpt":0.2705180046623379,"score_spread":0.2536877049514123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}