{"id":"W4308678741","doi":"10.1080/14789450.2022.2142564","title":"The role of E3 ubiquitin ligase in multiple myeloma: potential for cereblon E3 ligase modulators in the treatment of relapsed/refractory disease","year":2022,"lang":"en","type":"review","venue":"Expert Review of Proteomics","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Cereblon; Ubiquitin ligase; DNA ligase; Ubiquitin-Protein Ligases; Ubiquitin; Cancer research; Multiple myeloma; Chemistry; Biology; Cell biology; Genetics; DNA; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005229631,0.0005572936,0.0008595142,0.0009142451,0.0001493544,0.0006116856,0.0006556367,0.0009457078,0.003866934],"category_scores_gemma":[0.0005103703,0.0001185312,0.0005210512,0.0007666813,0.0002568979,0.0007729981,0.0004038198,0.001867335,0.001984456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005832702,"about_ca_system_score_gemma":0.0006487744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006216787,"about_ca_topic_score_gemma":0.001423806,"domain_scores_codex":[0.9998679,0.00002763593,0.00001337626,0.00002331039,0.00004854662,0.0000192342],"domain_scores_gemma":[0.9998165,0.00006831368,0.00003091714,0.000004629302,0.00006022988,0.00001952938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001913563,0.00005547827,0.0001042192,0.01149379,0.0001212979,0.0002074069,0.00003151383,0.00041979,0.002906722,0.0033584,0.06573315,0.9153769],"study_design_scores_gemma":[0.00006469292,0.0001838902,0.000628781,0.003079958,0.000126702,0.001026419,0.00003128924,0.0001417303,0.0008045407,0.001834976,0.9920627,0.00001420334],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001690393,0.9972767,0.0001342777,0.0008677985,0.000447685,0.000004898212,0.00002834107,0.00001079994,0.001060525],"genre_scores_gemma":[0.001288341,0.9961093,0.0001917156,0.0008364167,0.0003850619,0.000009627758,0.00006338675,0.00000287018,0.001113235],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003866934,"threshold_uncertainty_score":0.01293623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01979603153856042,"score_gpt":0.3074608902101088,"score_spread":0.2876648586715484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}