{"id":"W4308679807","doi":"10.1161/atvbaha.122.318062","title":"Apolipoprotein A1 Protects Against Necrotic Core Development in Atherosclerotic Plaques: PDZK1-Dependent High-Density Lipoprotein Suppression of Necroptosis in Macrophages","year":2022,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Necroptosis; Scavenger receptor; Cell biology; Apolipoprotein B; Biology; LDL receptor; Lipoprotein; Knockout mouse; Cancer research; Programmed cell death; Apoptosis; Receptor; Cholesterol; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002614357,0.0004355218,0.0003588882,0.0004116077,0.0002132183,0.0002967247,0.0003128272,0.0003630795,0.001377894],"category_scores_gemma":[0.0001198828,0.0001963672,0.0003974786,0.0001939604,0.0004291479,0.0002666362,0.0002190582,0.0008431138,0.0004335527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002819023,"about_ca_system_score_gemma":0.0003132907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003610777,"about_ca_topic_score_gemma":0.0005339963,"domain_scores_codex":[0.9998612,0.00001951425,0.00002106877,0.00002461183,0.00002624882,0.00004731105],"domain_scores_gemma":[0.9998209,0.00001550828,0.00005327492,0.0000208235,0.00001924777,0.0000703123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001413967,0.000234984,0.0001956622,0.00009261011,0.00001397293,0.00005147588,0.00002280293,0.00004999148,0.9965101,0.00009126254,0.00008481023,0.001238322],"study_design_scores_gemma":[0.0004289834,0.002386936,0.006023227,0.00001646169,0.00005789835,0.0002576146,0.00006417013,0.0007546456,0.9879831,0.0001053942,0.001911735,0.000009799863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954079,0.001509482,0.001348998,0.0002013419,0.00005680139,0.00005465808,0.0003864946,0.0001119487,0.0009221947],"genre_scores_gemma":[0.9940759,0.001198229,0.001609251,0.0000997309,0.00002509623,0.0001359303,0.0005434392,0.00002339426,0.002289024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001377894,"threshold_uncertainty_score":0.004609466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02063343047734617,"score_gpt":0.2452667925742886,"score_spread":0.2246333620969424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}